Pharmacology Week 1 Lecture

Question 1

What is neuropsychopharmacology?

Answer 1

Devoted to study of drugs that affect nervous tissue and affect behaviour

Question 2

Neuro-pharmacology is the Study of the effects of drugs on _______, their _______ and _______.

Answer 2

neurons
synapses
circuits

Question 3

What is psychopharmacology?

Answer 3

Effects of drugs on behaviour, including emotional states and cognition

Question 4

All drugs have ____ names

Answer 4

4

Question 5

Structure is ________

Answer 5

Function

Question 6

Communication in the central nervous system is a mixture of ______ and ______ methods

Answer 6

Chemical
Electrical

Question 7

Communication in the CNS occurs through specialised _____ called ______

Answer 7

Cells
Neurons

Question 8

T/F Neurons are permanent cells of the CNS

Answer 8

T

Question 9

There are _____ different types of ______

Answer 9

50
Neurons

Question 10

Dale’s Principle : one ______ uses only one type of ____________

Answer 10

neuron
neurotransmitter

Question 11

Primary Neurotransmitters are classified according to _____ or ______

Answer 11

chemical structure
speed of action

Question 12

Primary neurotransmitters are made up of _____, ______, and ______

Answer 12

amines
Amino acids
Peptides

Question 13

What are the criteria for a neurotransmitter?

Answer 13

Substance is synthesised within the neuron in which it is present

Enzymes, substrates necessary for its synthesis are present within the neuron

Substance released upon stimulation of neuron

Specific targets (receptors) located on post-synaptic neurons

Action is blocked by specific antagonists

External application of substance to receptor mimics endogenous actions

Action of substance is terminated by a specific mechanism

Question 14

S.T.A.R.S. criteria for neurotransmitters are:

Answer 14

Synthesis
Termination
Antagonists
Release
Storage

Question 15

The two main mechanism of action of drugs are:

Answer 15

agonist
antagonist

Question 16

The _______ is the long, thin structure in which action potentials are generated; the transmitting part of the neuron. After initiation, action potentials travel down ______ to cause release of neurotransmitter.

Answer 16

Axon
axons

Question 17

A _____ is the receiving part of the neuron. ________ receive synaptic inputs from axons, with the sum total of _________ inputs determining whether the neuron will fire an action potential.

Answer 17

Dendrite
Dendrites
dendritic

Question 18

The small protrusions found on dendrites that are, for many synapses, the postsynaptic contact site are called:

Answer 18

Spine

Question 19

A chemical released from a neuron following an action potential. The _______ travels across the ________ to excite or inhibit the target ________.

Answer 19

neurotransmitter
synapse
neuron

Question 20

The junction between the axon of one neuron and the dendrite of another, through which the two neurons communicate is called the:

Answer 20

Synapse