Pharmacology Tolerance And ADR

Question 1

Continued agonist stimulation cause decrease number of receptor by endocytosis

Answer 1

Receptor down-regulation

Question 2

Continued antagonist inhibition cause increase of number of receptors

Answer 2

Receptor up-regulation

Question 3

Response to a drug decreases with repeated intake for days or
weeks, and higher dose is needed to reach the same effect

Answer 3

Tolerance

Question 4

acute tolerance after few minutes, but the same effect is not reached even with increasing the drug dose

Answer 4

Tachyphlaxis

Question 5

Harmful effects occurring at doses intended for therapeutic effects.

Answer 5

Adverse drug reaction

Question 6

Deposition of antigen-antibody-complement complexes in small blood vessels.
example : serum sickness
Drug : penicillin

Answer 6

Type III immune complex ( hypersensitivity reaction)

Question 7

Osteoporosis caused by use of chronic corticosteroids(drug) intake

Answer 7

Type C continuous

Question 8

Teratogeniciy (defect in babies of pregnant patients) as after intake of retinoids (derivative of vitamin A used to treat skin conditions) what type ?

Answer 8

Type D delayed