Pharmacology revision Flashcards
GH agonists example (2)
Somatropin
Mecasermin
GH agonist uses
Growth hormone deficiency/ Growth disorders
GH antagonists example and use
Pegyisomant
- Acromegaly
Prolactin antagonist and uses
Cabergoline
Bromocritine
Quinagolide
Use
- Hyperprolactinoma
ADH antagonist
- Example
- Use
Demeclocycline
- Use for SIADH
Thyroid agonist
Thyroxine
Tri-iodothyronine
Teriparatide
PTH agonist
- Use for osteoporosis
PTH antagonist
- Use
Cinacelcet
- Calcium receptor agonist
Treats tertiary hyperparathyroidism
Insulin antagonist
- And its use
Diazoxide
- Insulinoma
Oestrogen agonist examples and uses
Estradiol
- Menopausal hormonal replacement
Ethinylestradiol
- Female hypogonadism
- Contraception
Mifepristone
Progesterone antagonist
- Used for termination of pregnancy
Mineralocorticoid antagonist example and uses
Spironolactone
- Conn’s syndrome
- Liver cirrhosis
- Severe heart failure
Goserlin/ Zoladex
- Drug type
- Administration
- Mechanism
- Indication
- Adverse effects
GnRH agonist
- Down regulates GnRH receptors
- Initiate increase then decreased progesterone/ testosterone
Administration
- Injection
- Non-pulsatile fashion
Indication
- Endometriosis
- Breast cancer
- Prostate cancer
Adverse effects
- Menopausal like symptoms
Clomifene
- Drug type
- Administration
- Mechanism
- Indication
- Adverse effects
Oestrogen receptor antagonist
- Inhibits negative feedback control of oestrogen on gonadotrophins
Indications
- Female infertility (ovarian hyperstimulation/ stimulation)
Adverse effects
- Vasomotor flushes
- Abdominal discomfort
- Visual blurring
- Cyst formation/ ovarian enlargement
Progesterone- only oral contraceptive
- Example
- Mechanism
- Indication
- Adverse effects
Example
- Norethisterone
- Levonorgestrel
- Desogestrel
Mechanism
- suppresses LH surge, inhibits ovulation
- Thickens cervical mucus
- Hostile endometrium
Adverse effects
- Menstrual irregularity
- Nausea
- Vomitting
- Headache
