Pharmacology / Pain / Anxiety Control 2% 1Q Flashcards
name 3 drugs known to cause gingival hyperplasia
Procardia (Ca+ channel blocker)
Cyclosporin
Dilantin
Peak pain after ortho adjustments when? Decreases over next ___- ___ days
the day after
6-8 days
NSAIDs given pre-op (increase / decrease) prostaglandin production which will (increase / decrease) inflammatory response and (increase / decrease) post-op pain, which (increase / decrease) pain threshold. They also (increase / decrease) the rate of tooth movement.
decrease
decrease
decrease
increase
decrease
Which prostaglandin can be detected in crevicular fluid during ortho treatment?
Prostaglandin E
Local injections of prostaglandin E causes appearance of ____________ and subsequent bone _____________ in rats
osteoclasts
resorption
Local injections of prostaglandin E causes a(n) (increase / decrease) in tooth movement in humans and monkeys
increase
What molecule is associated with IFN-Gamma, IL-1, TNF-alpha
Prostaglandin E
Low doses of prostaglandin E inhibitors have what effect on tooth movement?
little to no effect
why does Acetaminophen have no effect on tooth movement?
it acts centrally
what is a contraindication for the use of Probanthine?
glaucoma
Probanthine causes what oral side effect?
reduced salivary flow
Probanthine is an anticholinergic, (sympathetic / parasympathetic agonist)
parasympathetic
name the 4 major Non-Selective NSAIDs
- Asprin
- ibuprofen
- naproxen
- ketoprofen
Non-Selective NSAIDs Inhibit both protective ______ and inflammatory ______ enzymes and are effective in alleviating acute inflammatory pain, chronic myofacial pain, and TMD associated pain
COX-1
COX-2
The risks associated with non-Selective NSAIDs
Risk of GI ulceration
bleeding
renal toxicity
COX-2 Inhibitors are also known as
COX -1 sparing drugs
the COX -2 inhibitor Celecoxib (celebrex) (is / is not) effective in acute post-op pain
is not
the COX -2 inhibitor Refecoxib (Vioxx) is a beneficial option because:
it is long lasting - up to 24hours
the main effect of NSAIDs and coxs is that they inhibit the production of ____________
prostaglandins
Leukotriene 6 is produced by ____________________ pathway and plays a role in tooth movement
arachidonic acid
Steroids block the initiation of what?
the arachidonic acid pathway
are bisphosphonates an absolute contraindication for orthodontic Tx?
no
Bisphosphonates what what effect on tooth movement ?
Inhibit
T/F: Bisphosphonates can cause osteonecrosis
True
Bisphosphonates ( increase / decrease ) wound healing nd ( increase / decrease ) mineral density
decrease
increase
Bisphosphonates affect osteosarcoma ( blasts / clasts )
osteoclasts
PTH has what effect on tooth movement?
Increase/enhance
Thyroxin has what effect on tooth movement?
Increase / Enhance
AHA recommends antibiotic prophylaxis for patients undergoing “_____________ orthodontic procedures”
extensive
Your recommendation for pain relief for a Hemophiliac patient would be
acetaminophen
Which type of hemophilia is most common? Is it X linked?
Hemophilia A
Yes
