Pharmacology / Pain / Anxiety Control 2% 1Q

Question 1

name 3 drugs known to cause gingival hyperplasia

Answer 1

Procardia (Ca+ channel blocker)

Cyclosporin

Dilantin

Question 2

Peak pain after ortho adjustments when? Decreases over next ___- ___ days

Answer 2

the day after

6-8 days

Question 3

NSAIDs given pre-op (increase / decrease) prostaglandin production which will (increase / decrease) inflammatory response and (increase / decrease) post-op pain, which (increase / decrease) pain threshold. They also (increase / decrease) the rate of tooth movement.

Answer 3

decrease

decrease

decrease

increase

decrease

Question 4

Which prostaglandin can be detected in crevicular fluid during ortho treatment?

Answer 4

Prostaglandin E

Question 5

Local injections of prostaglandin E causes appearance of ____________ and subsequent bone _____________ in rats

Answer 5

osteoclasts

resorption

Question 6

Local injections of prostaglandin E causes a(n) (increase / decrease) in tooth movement in humans and monkeys

Answer 6

increase

Question 7

What molecule is associated with IFN-Gamma, IL-1, TNF-alpha

Answer 7

Prostaglandin E

Question 8

Low doses of prostaglandin E inhibitors have what effect on tooth movement?

Answer 8

little to no effect

Question 9

why does Acetaminophen have no effect on tooth movement?

Answer 9

it acts centrally

Question 10

what is a contraindication for the use of Probanthine?

Answer 10

glaucoma

Question 11

Probanthine causes what oral side effect?

Answer 11

reduced salivary flow

Question 12

Probanthine is an anticholinergic, (sympathetic / parasympathetic agonist)

Answer 12

parasympathetic

Question 13

name the 4 major Non-Selective NSAIDs

Answer 13

1. Asprin
2. ibuprofen
3. naproxen
4. ketoprofen

Question 14

Non-Selective NSAIDs Inhibit both protective ______ and inflammatory ______ enzymes and are effective in alleviating acute inflammatory pain, chronic myofacial pain, and TMD associated pain

Answer 14

COX-1

COX-2

Question 15

The risks associated with non-Selective NSAIDs

Answer 15

Risk of GI ulceration

bleeding

renal toxicity

Question 16

COX-2 Inhibitors are also known as

Answer 16

COX -1 sparing drugs

Question 17

the COX -2 inhibitor Celecoxib (celebrex) (is / is not) effective in acute post-op pain

Answer 17

is not

Question 18

the COX -2 inhibitor Refecoxib (Vioxx) is a beneficial option because:

Answer 18

it is long lasting - up to 24hours

Question 19

the main effect of NSAIDs and coxs is that they inhibit the production of ____________

Answer 19

prostaglandins

Question 20

Leukotriene 6 is produced by ____________________ pathway and plays a role in tooth movement

Answer 20

arachidonic acid

Question 21

Steroids block the initiation of what?

Answer 21

the arachidonic acid pathway

Question 22

are bisphosphonates an absolute contraindication for orthodontic Tx?

Answer 22

no

Question 23

Bisphosphonates what what effect on tooth movement ?

Answer 23

Inhibit

Question 24

T/F: Bisphosphonates can cause osteonecrosis

Answer 24

True

Question 25

Bisphosphonates ( increase / decrease ) wound healing nd ( increase / decrease ) mineral density

Answer 25

decrease

increase

Question 26

Bisphosphonates affect osteosarcoma ( blasts / clasts )

Answer 26

osteoclasts

Question 27

PTH has what effect on tooth movement?

Answer 27

Increase/enhance

Question 28

Thyroxin has what effect on tooth movement?

Answer 28

Increase / Enhance

Question 29

AHA recommends antibiotic prophylaxis for patients undergoing “_____________ orthodontic procedures”

Answer 29

extensive

Question 30

Your recommendation for pain relief for a Hemophiliac patient would be

Answer 30

acetaminophen

Question 31

Which type of hemophilia is most common? Is it X linked?

Answer 31

Hemophilia A

Yes