Pharmacology: Opioid Tolerance + Dependence Flashcards
Define tolerance
What is dependence?
What is cross-tolerance?
When can tolerance to morphine be detected?
List side effects of morphine
_____ side effects _____ dose escalation
Mechanism of opioid tolerance
- What are opioids substrates of?
- What occurs when agonist is repeatedly stimulated?
Mechanisms of opioid receptor desensitisation
What is opioid-induced hyperalgesia?
How can we combat opioid tolerance?
Name a serious condition due to opioid tolerance + withdrawal
What happens when patient withdraws after chronic administration of opioids?
When are withdrawal symptoms at its climax/max + when do they disappear?
What helps treat acute opioid toxicity?
What helps treat withdrawal symptoms?
What is substitution therapy?
What is used during therapy + describe differences?
If substitution therapy fails, what can patient use to prevent relapse?
