Pharmacology: Arachidonic Acid Metabolism + NSAIDs Flashcards
Complete 2nd podcast
1
Q
What are the main actions of NSAIDs?
A
2
Q
What are the main side effects of NSAIDs?
A
3
Q
What is NSAIDs molecular target + describe the pharmacological basis
A
4
Q
Step 1 of prostaglandin synthesis
A
5
Q
What PLA2 enzyme is important for arachidonic acid release?
A
6
Q
How is cPLA2 regulated?
A
7
Q
Step 2 of prostaglandin synthesis
A
8
Q
What is another name for COX?
A
9
Q
Describe COX structural features
A
10
Q
What is responsible for dimerisation?
A
11
Q
Which COX enzyme is expressed all the time (constitutively)?
A
12
Q
COX-2 is inducibly expressed.
- What induces COX-2?
- What suppresses COX-2?
A
13
Q
Name the cells which all the prostaglandin’s are produced + synthases found in?
A
14
Q
What is the function of each prostaglandin?
A
15
Q
Step 3 of prostaglandin synthesis
A
