Pharmacology: Arachidonic Acid Metabolism + NSAIDs

Question 1

What are the main actions of NSAIDs?

Question 2

What are the main side effects of NSAIDs?

Question 3

What is NSAIDs molecular target + describe the pharmacological basis

Question 4

Step 1 of prostaglandin synthesis

Question 5

What PLA2 enzyme is important for arachidonic acid release?

Question 6

How is cPLA2 regulated?

Question 7

Step 2 of prostaglandin synthesis

Question 8

What is another name for COX?

Question 9

Describe COX structural features

Question 10

What is responsible for dimerisation?

Question 11

Which COX enzyme is expressed all the time (constitutively)?

Question 12

COX-2 is inducibly expressed.

• What induces COX-2?
• What suppresses COX-2?

Question 13

Name the cells which all the prostaglandin’s are produced + synthases found in?

Question 14

What is the function of each prostaglandin?

Question 15

Step 3 of prostaglandin synthesis

Question 16

Step 4 of prostaglandin synthesis

Question 17

How do prostaglandins leave cell after being synthesised?

Question 18

Step 5 of prostaglandin synthesis