Pharmacology of T2DM Flashcards
1
Q
What class of drug is metformin?
A
Biguanide
2
Q
Do biguanides affect insulin release?
Do they therefore cause hypo’s?
A
No and no
3
Q
What is first line diabetic treatment medication?
A
Metformin
4
Q
What is second line T2DM treatment?
A
Metformin AND
…sulfonylurea (gliclazide)
…gliptin
…thiazolidinedione (pioglitazone)
5
Q
What does metformin do?
A
Increases insulin sensitivity
6
Q
What does gliclazide do?
A
Increase insulin secretion
7
Q
Can sulfonylureas cause hypos?
A
Yes
8
Q
What do thiazolidinediones do?
A
Increase insulin sensitivity
9
Q
Explain gliptins, including the enzyme they work on.
A
DPP-4 inhibitors
Reduce glucagon levels
