IBD Flashcards
What are the 2 types of IBD?
Differentiate them.
1) ulcerative colitis = large colon only / inner 1/3 / continuous inflammation
2) crohns = mouth to anus / transmural (all layers of colon) / skip lesions
What is the M:F ratio of crohns and UC?
1:1 for both
What is the onset age for UC?
Bi-modal = 20’s and 50’s
Which IBD condition has a larger genetic component?
Crohns
What would bloods for IBD show?
Raised inflammatory markers (CRP/ESR)
Low albumin
Anaemia (iron deficiency due to malabsorption)
Low LFT’s
Faecal calprotectin raised
What is faecal calprotectin?
Like ‘CRP’ for the bowel
What is the gold standard for UC diagnosis?
Endoscopy
Where does UC start and where does it progress to?
Rectum = start
Can travel whole length of colon progressively:
- proctitis
- left-sided colitis
- pan-colitis
What is the treatment for UC?
Steroids Aminosalicyates Immunosuppressants (methotrexate/azathioprine) Biologics Surgery
What is another name for the aminosalicylate drug group?
5-ASA (Mesalazine)
Topical
Where would each of these stomas be located?
1) colostomy
2) iliostomy
3) urostomy
1) colostomy = LIF
2) iliostomy = RIF
3) urostomy = RIF
What is a loop versus an end colostomy?
End = one opening
Loop = 2 (to allow a anastomoses distally to heal post-surgery)
What is the onset age for crohns?
20-30
Which race is at greater risk of crohns?
White
What is the genetic concordance of crohns?
58% monozygotic twins
What added sign/symptom is seen in crohns compared to UC?
Oral ulceration
Perianal abscess
What can faecal calprotectin indicate?
IBD over IBS but NOT between crohns or UC
What can RIF pain indicate?
IBD over IBS
Which IBD condition can give you nutritional deficiencies?
Crohns
Which IBD can give you fistula and strictures?
Crohns
What histological findings are seen in UC?
Crypt abscesses
Mucosal lining inflammation only
What histological findings are seen in UC?
Granulomas
Transmural full thickness inflammation
Is smoking detrimental to both IBD diseases?
Yes to crohns
Protective for UC!
