Pharmacology of Substance Abuse (pharm of recreational drugs) Flashcards
How do most CNS depressants work?
most augment activity at GABA A receptor complexes–> increasing Cl- influx–> hyperpolarization of the cell–> Inhibitory actions
What 2 major factors does alcohol absorption depend upon?
- Concentration of alcoholic beverages
2. Stomach: empty vs. full
What drug is used for aversion therapy to help treat chronic alcoholism?
Disulfiram–> inhibits aldehyde dehydrogenase, resulting toxicity form acetaldehyde–> leads to symptoms such as pulsating headache, nausea, hot, vomiting, chest pain, weakness, dizziness, etc…
Treatment(s) for methanol or ethylene glycol poisoning?
- Ethyl alcohol
2. An alcohol dehydrogenase inhibitor- Fomepizol
What is the main mechanism of the CNS stimulant drugs (methamphetamine, cocaine etc.)?
increase CNS catecholamine/dopamine activity
How does cocaine specifically work?
inhibits uptake of NE, DA and 5HT
How do amphetamines and the cathinone synthetic drugs work?
reverse the transporters for NE, DA and 5HT causing their release
What is the mechanism of caffeine?
antagonist at inhibitory adenosine receptors
What is the mechanism of nicotine?
activates nAChRs on VTA dopamine neurons leading to increased DA release in nucleus accumbens and prefrontal cortex
Which receptor do the hallucinogens target?
5HT
Which receptors do the opiates target?
opioid
Which receptors do cannabis work through?
cannabinoid
What is the more specific mechanism of action of LSD, mescaline and psilocybin?
- agonist at 5HT2A receptors on Raphe cell bodyleading to inhibition of Raphe Nuclei firing and increased sensory input
- partial dopamine agonist
- *all show cross tolerance with each other**
What are some of the side effects of LSD, mescaline and psilocybin?
- bad trips (anxiety attack, panic attack)
- flashbacks
- “street drug” lifestyle
- *no overdoses, birth defects, or chronic psychoses linked to LSD**
What is the more specific mechanism of PCP?
- antagonist of ion channel associated with NMDA
- agonist at mu-opioid receptor