Narcotic Analgesics Flashcards
What is the mechanism of action of all of the following drugs? Morphine Codeine Tramadol Dentanyl Mathadone Oxycodone Meperidine Propoxyphene
Mu-opioid receptor agonists
Which of the Mu-opioid receptor agonists also inhibits NE/5HT uptake leading to analgesia and is a synethetic analog of codeine?
tramadol
Which of the Mu-opioid receptor agonists has low affinity to the receptor but can be demethylated to morphine within the body?
Codeine
What is morphine generally used for?
- severe analgesia
- mood alteration
- antitussive
- sedation
What is Codeine generally used for?
- moderate analgesia
- antitussive
What is tramadol generally used for?
moderate analgesia
What is fentanyl generally used for?
Severe analgesia after identification of dose level via other opiod (e.g., morphine)
What is methadone generally used for?
- chronic, severe pain
- treatment of heroin and opiod addicts
What is oxycodone generally used for?
moderate to severe analgesia
What is Meperidine and propoxyphene used for?
not used anymore
What are the common side effects of all of the mu-opioid receptor agonsits?
- miosis
- constipation
- respiratory depression
- dry mouth
- nausea/vomiting
- sedation
- sweating
- dreams
- dysphoria
- delerium
- myoclonus
- seizures
- pruritis
- urticaria
- urinary incontinence
Which of the mu opioid receptor agonists can also have a side effect of mental status changes and seizures?
Meperidine
Which of the mu opioid receptor agonists can also have a side effect of CNS toxicity?
propoxyphene
How is oxycontin different from oxycodone?
oxycontin is extended release
Which of the mu opioid receptor agonists should not have their doses changed more than 1x per week?
methadone and fentanyl
