Alzheimers

Question 1

Name the 4 AchE inhibitors used to treat Alzheimers and which ones also inhibit BuChE?

Answer 1

Tacrine
Donezepil
Rivastigmine
Galantamine
**Tacrine and Rivastigmine also inhibit BuChE**

Question 2

Which of the AChE inhibitors is also an allosteric modulator nicotinic receptors?

Answer 2

Galantamine

Question 3

What is the mechanism of memantine and what are he side effects?

Answer 3

-it is a partial antagonist of NMDA receptors

side effects-dizziness, confusion, headache and constipation

Question 4

Which 2 of the following are used in severe alzheimers? Tacrine, Donezepil, Rivastigmine, Galantamine or Memantine

Answer 4

Donezepil and Memantine

Question 5

What are the side effects of the AChE inhibitors?

Answer 5

nausea and vomitting
Tacrine- + diarrhea and abd cramping, transaminase elevation
Donezepil, Rivasigmine and Galantamine- + sleep disturbance

Question 6

Which of the alzheimers drugs are metabolized by P450?

Answer 6

Tacrine, Donezepil and Galantamine

Question 7

Which of the alzheimers drugs are hydrolyzed by cholinesterase?

Answer 7

Rivastigmine

Question 8

Which of the alzheimers drugs are excreted in the urine unchanged?

Answer 8

Memantine