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xB13W4 > PHARMACOLOGY OF RHYTHM CONTROL > Flashcards

PHARMACOLOGY OF RHYTHM CONTROL Flashcards

1
Q

what classification is used for antiarrythmics?

A

vaughan williams classification

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2
Q

what are the classes in the vaughan williams classification?

A 
class 1 - Na+ channel blockers
class 2 - beta blockers
class 3 - K+ channel blockers
class 4 - Ca2+ channel blockers
class 5 0 agents that work by other moa
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3
Q

what are the 3 types of Na+ channel blockers?

A 
class 1 a - lengthens the action potential
class 1b - shortens the action potential
class 1c - no effect on action potential
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4
Q

what are examples of class 1a from vaughan williams classification?

A

dispyramide
quinidine
procainamide

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5
Q

what are examples of class 1b from vaughan williams classification?

A

lidocaine and phenytoin

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6
Q

what are examples of class 1c from vaughan williams classification?

A

flecanide and propafenone

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7
Q

what are examples of beta blockers?

A

atenolol and brisopolol

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8
Q

what are examples of K+ channel blockers?

A

amiodarone and sotalol

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9
Q

what are examples of Ca2+ channel blockers?

A

verapamil and diltiazem

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10
Q

what are examples fo class 5 agents on the vaughan williams classification?

A

adenosine
digoxin
magnesium
atropine

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11
Q

what is a DC sock?

A

direct current cardioversion defibrilation

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12
Q

what type of drug is digoxin?

A

a digitalis glycoside

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13
Q

what is digoxins moa?

A

inhibting Na+/K+ ATPase which increases intracellular Na+ which then drives the influx of Ca2+ into the heart causing increased contractility

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14
Q

what are side effects of digoxin

A 
confusion
dizzy
nausea and vomiting
diarrhoea
vision changes
skin rashes
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15
Q

what are contraindications for digoxin?

A 
acute MI
hypersensitivity
ventricular fibrillation
myocarditis
hypomagnesemia
hypokalaemia
wolf-Parkinson-white syndrome
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16
Q

what is lidocaines moa?

A

blocks N+ channels so the heart is less likely to conduct early action potentials which may be causing arrythmias

17
Q

what are side effects of lidocaine?

A 
bluish lips/fingernails/palms
double vision
chest pain
cold/clammy/pale
tinnitus
difficultu breathing and swallowing
dizziness
18
Q

what are side effects of beta blockers?

A 
fatigue
dizzy
cold extremiirs
difficulty sleeping and nightmares
nausea
19
Q

what are side effects of Ca2+ channel blocker?

A

cosntipation
worsening cardiac outpit
bradycardia

20
Q

what is amiodarones moa?

A

blocks k+ channels which relaxes smooth muscle lining bascular walls = decreases afterload

21
Q

what is atropines moa?

A

it competitively blocks effects of ACh at muscrinic cholinergic receptors on cardiac muscle

xB13W4 (5 decks)

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