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MoDA Drugs > Pharmacology of peripheral neurotransmission > Flashcards

Pharmacology of peripheral neurotransmission Flashcards

1
Q

Triethylcholine

A

Competitive substrate for choline acetyl trasferase

Makes false transmitter

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2
Q

Vesamicol

A

Inhibits vAChT for loading ACh into vesicles

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3
Q

alpha-bungarotoxin

A

binds nAChR at NMJ (not at ganglion) to block

Irreversible

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4
Q

beta-bungarotoxin

A

blocks ACh release via structural changes to pre-synaptic terminal

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5
Q

alpha latrotoxin

A

forms pre-synaptic Ca2+ channels

Increases ACh release

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6
Q

Trimethapham

A

competitive antagonist of nerve nAChR

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7
Q

Hexamethonium

A

use dependent antagonist of nerve nAChR

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8
Q

Suxamethonium

A

NMJ nM agonist (causes block) for tracheal intubation

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9
Q

Decamethonium

A

Depolarising blocker of NMJ nM

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10
Q

Curare and alpha bungarotoxin

A

NMJ nM antagonist to cause non-depolarising block and flaccid paralysis

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11
Q

Tetracycline

A

Chelates Ca2+ to inhibit NMJ

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12
Q

Aminoglycosides

A

Inhibit CaV to decrease ACh

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13
Q

BoTX

A

Cleaves synaptobrevin at NMJ cholinergic neutrons

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14
Q

TeNT

A

Cleaves synaptobrevin at inhibitory interneurons in CNS

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15
Q

Edrophonium

A

AChE used to diagnose myasthenia gravid and treat glaucoma

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16
Q

Neostigmine

A

AChE used to treat myasthenia gravis

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17
Q

Rivastigmine

A

Anticholinesterase

To treat Alzheimers

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18
Q

Sarin/Novichok

A

Irreversible AChE
Use atropine as antidote to cause tachycardia (via blocking M2 stimulation on the heart) and Pralidoxime to regenerating cholinesterase

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19
Q

Bethanechol

A

ACh agonist to stimulate detrusor muscle via M3

20
Q

Pilocarpine

A

ACh agonist used to increase salivation and lacrimal secretion via action on M3

21
Q

Atropine

A

Blocks M2 stimulation on heart to treat bradycardia

22
Q

Ipratropium

A

Blocks M2 stimulation in asthma

23
Q

Tropicamide

A

Blocks M3 stimulation on pupil to cause dilation (mydriasis)

24
Q

Solifenacin

A

M3 selective blocker to inhibit detrusor contraction

25
Q

Glycopyronium

A

Blocks M3 to stop excessive drooling

26
Q

Phenylephrine

A

alpha1 selective agonist

Causes mydriasis and nasal decongestion

27
Q

Clonidine

A

alpha2 selective agonist to inhibit transmitter reease

- Reduces BP

28
Q

alpha-methyl DOPA

A

false transmitter with alpha2 selectivity

29
Q

Isoprenaline

A

beta agonist
Bronchodilation via B2
Increased heart rate via B1

30
Q

Dobutamine

A

beta1 agonist to increase CO

31
Q

Salbutamol

A

beta2 agonist to relieve bronchospasm

32
Q

Mirabegran

A

beta2 agonist to relax detrusor

33
Q

Prazosin

A

alpha1 antagonist for treating hypertension

34
Q

Yohimbine

A

alpha2 antagonist to reverse veterinary sedation

35
Q

Propanolol

A

beta antaongist to decrease HR

36
Q

Atenolol

A

beta1 selective antagonist to treat hypertension

37
Q

alpha methyl tyrosine

A

pseudo substrate for TOH (rate limiting step of catecholamine synthesis)

38
Q

Carbidopa

A

inhibits dopa decarboxylase

39
Q

methyldopa

A

converted to false transmitter with highest affinity for pre-synaptic alpha2 recpetors

40
Q

Reserpine

A

irreversibly binds VMAT2 to block uptake of catecholamines to load vesicles

41
Q

Tetrabenzamine

A

reversibly binds VMAT2

Used in Huntington’s

42
Q

Guanethidine

A

taken into nerves by NET and vesicles by VMAT2, depleting it of NA
Causes HR to fall

43
Q

Dexamfetamine

A

taken into nerves by NET and into vesicles by VMAT2, in exchange for NA which leaks out so promotes release

44
Q

Ephidrine

A

indirectly causes NA release and acts on post synaptic receptors
Nasal decongestant

45
Q

Tricyclic antidepressants and cocaine

A

Block high affinity low capacity uptake 1 using NET

46
Q

Steroid hormone blocking uptake

A

Blocks uptake 2 using EMT

47
Q

Phenoxybenzamine

A

alpha antagonist to counteract large Adr released during adrenal gland removal

MoDA Drugs (9 decks)

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