Pharmacology of Inflammation Flashcards
vasoactive amine found in most tissue in the body
VD - Blood vessels
HISTAMINE
precursor of histamine
Histidine
Histamine prduced by
Platelets
Basophils
Mast cell
release histamine
produced by connective tissue
allergey
Mast Cell
H1-
H2
H3
H1- Blood vessels
H2- Stomach- ⬆️ Gastric irritation
H3- CNS - ⬇️ CNS activity
MOA of H1 Blockers
It competes with free histamine binding at a recepter site - Competitive Antagonism
It depresses the CNS activity causing sedation
H1
bronchial response
Constrict
most common H1 blocker - 1st generation
Diphenhydramine (Benadryl)
most common for pre-operative sedation
Promethazine (Phenergan)
Gastric Ulcer
Pernicious Anemia - Schilling Test
Peptic Ulcer
Iron Deficiency Anemia
Peptic Ulcer
Duodenum
Gastritis
Stomach
most common 2nd generation H1 Blocker
Cetirizine HCL
most dangerous , acute allergic reaction occuring after drug administration . lead to stroke
ANAPHYLACTIC SHOCK
TX: Epi (1:1000) - IV/ IM
perform CPR loss of consciousness
most found stommach that ⬆️ gastric secretion
H2 Histamine
are used to tx gastric , peptic , GERD, Zollinger Ellison Syndrome
H2 Blockers (anti-histamine)
most common drug for GERD
Cimetidine
⬇️ gastric secretion
component of Antacids that don’t induce vomiting
Magnesium
Aluminum
Arachidinoc Acid (2) Pathways
- Lipooxygenase Pathway
2. Cyclooxygenase Pathway
Lipooxygenase Pathway
- Leukotrienes- Bronchoconstriction (Lungs)
steroids➡️ inhibit phopholipase A2
Asthma
Types: Intrinsic & Extrinsic
Intrinsic - Environment
Extrinsic- Stress
Cyclooxygenase Pathway
- Thromboxane A- platelet, Platelet Aggregation
- Prostacycline A- endothelium, thromboxane A
- Prostaglandins- pain , fever & inflammation
