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DLE > Pharmacology of Inflammation > Flashcards

Pharmacology of Inflammation Flashcards

1
Q

vasoactive amine found in most tissue in the body

VD - Blood vessels

A

HISTAMINE

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2
Q

precursor of histamine

A

Histidine

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3
Q

Histamine prduced by

A

Platelets
Basophils
Mast cell

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4
Q

release histamine
produced by connective tissue
allergey

A

Mast Cell

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5
Q

H1-
H2
H3

A

H1- Blood vessels
H2- Stomach- ⬆️ Gastric irritation
H3- CNS - ⬇️ CNS activity

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6
Q

MOA of H1 Blockers

A

It competes with free histamine binding at a recepter site - Competitive Antagonism
It depresses the CNS activity causing sedation

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7
Q

H1

bronchial response

A

Constrict

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8
Q

most common H1 blocker - 1st generation

A

Diphenhydramine (Benadryl)

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9
Q

most common for pre-operative sedation

A

Promethazine (Phenergan)

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10
Q

Gastric Ulcer

A

Pernicious Anemia - Schilling Test

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11
Q

Peptic Ulcer

A

Iron Deficiency Anemia

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12
Q

Peptic Ulcer

A

Duodenum

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13
Q

Gastritis

A

Stomach

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14
Q

most common 2nd generation H1 Blocker

A

Cetirizine HCL

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15
Q

most dangerous , acute allergic reaction occuring after drug administration . lead to stroke

A

ANAPHYLACTIC SHOCK
TX: Epi (1:1000) - IV/ IM
perform CPR loss of consciousness

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16
Q

most found stommach that ⬆️ gastric secretion

A

H2 Histamine

17
Q

are used to tx gastric , peptic , GERD, Zollinger Ellison Syndrome

A

H2 Blockers (anti-histamine)

18
Q

most common drug for GERD

A

Cimetidine

⬇️ gastric secretion

19
Q

component of Antacids that don’t induce vomiting

A

Magnesium

Aluminum

20
Q

Arachidinoc Acid (2) Pathways

A
  1. Lipooxygenase Pathway

2. Cyclooxygenase Pathway

21
Q

Lipooxygenase Pathway

A
  1. Leukotrienes- Bronchoconstriction (Lungs)
22
Q

steroids➡️ inhibit phopholipase A2

A

Asthma
Types: Intrinsic & Extrinsic
Intrinsic - Environment
Extrinsic- Stress

23
Q

Cyclooxygenase Pathway

A
  1. Thromboxane A- platelet, Platelet Aggregation
  2. Prostacycline A- endothelium, thromboxane A
  3. Prostaglandins- pain , fever & inflammation

DLE (14 decks)

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