ANALGESICS

Question 1

PAra- aminophenols
effects:
Organ:

Answer 1

Anti-pyretic & Analgesic

Liver

Question 2

inhibit prostaglandin going hypothalamus

Answer 2

Antipyretic

Question 3

Main advantage non-narcotic

narcotics

Answer 3

1. Non- narcotic- drug dependence

2. Narcotics- alleviates severe pain

Question 4

safest non narcotic drugs
Pregnant & Hemophilia
No GI Irritation

Answer 4

Acetaminophen ( Paracetamol)

Question 5

Adverse Effect of Acetaminophen (Paracetamol)
Antidote:
Contraindicated:

Answer 5

Hemolytic Anemia
Hepatic Necrosis
N- acetylcysteine
Hangover

Question 6

Phenacetin
Orgin:
Active Components
Adverse Effect:

Answer 6

Acetanalidine
acetaminophen
Methemoglobinemia- no O2 in the blood

Question 7

Signs of Methemoglobinemia

Answer 7

Cyanosis
Dyspnea
Anemia

Question 8

maximim dose of Acetaminophen

Answer 8

4000 (8tablets)

Question 9

NSAIDS
effect:
Maximum dose/day:
Contraindications:
MOAs

Answer 9

Anti-inflammatory & Analgesic
3,600mg
Asthma ; Chronic Kidney Disease
* Inhibit prostaglandin synthesis
* interfere with platelet function
* cause peptic ulcerations

Question 10

less GI effect:
Most GI effect
No GI

Answer 10

Ibuprofen
Aspirin
Acetaminophen

Question 11

Tx. Gouty Arthritis

Answer 11

Allopurinol- decreases uric acid

Question 12

anti inflammatory of Gout

Answer 12

Pyrazolone

Question 13

most potent inhibitor of Prostaglandins

Answer 13

Cox- inhibitor

Question 14

used internally & px with allergy to apirin

Answer 14

Sodium salicylate

Question 15

used in dysmenorrhea

Answer 15

Phenylpropiomic Acid derivative

Question 16

least potent inhibitor of prostaglandins, Mainly in GIT that produces GI irritation, Main concern drug in patients with coronary artery disease

Answer 16

Aspirin

Question 17

active component of Aspirin

Answer 17

Acetyl salicylic Acid

Question 18

Reye’s Syndrome

Answer 18

Liver= Hepatitis
Brain= Encephalitis
Middle ear= Otitis Media

Question 19

Aspirin

antidote

Answer 19

Sodium Bicarbonate

Question 20

most potent inhibitor cyclooxygenase / prostaglandin

Answer 20

Cox2 inhibitor

Question 21

Px. taking aspirin

⬆️ bleeding time

Answer 21

Stop aspirin for 7 days

Question 22

acquired tolerance from repeated exposure to a particular stimulus

Answer 22

Habituation

Question 23

phenomenon of decreased responsiveness to a drug ff. chronic administration

Answer 23

Tolerance

Question 24

came from poppy plant

Answer 24

Opioid (Opiates)

Question 25

gold standard
Triad:
Special receptor:
Dosage:

Answer 25

Miosis, Coma, Respiratory Depression
Mu- receptor
10-15mg

Question 26

Glasgow Coma Scale

Answer 26

Eye opnening
Verbal response
Motor response

Question 27

antidote of Morphine

Answer 27

Methadone

Question 28

cough reflex & constipation

dosage:

Answer 28

Codeine (Methyl morphine)

0.5 - 1gr (30-60mg)

Question 29

Codeine + Acetaminophen

Answer 29

Tylenol

Question 30

methoxylation

acetylation

Answer 30

Morphine

Heroin

Question 31

highly addictive. Used in MI ( IV)
ro respiratry depression
mimic endorphin
cannot prescribed

Answer 31

Heroin

Question 32

opiod antagonist

Answer 32

Naloxone (Narcan)

Question 33

Naloxone

Withdrawal

Answer 33

1. Mydriasis
2. Lacrimation
3. Yawning
4. Diarrhea

Question 34

potent narcotic analgesic
more potent than morhine
also avialable Lollipop

Answer 34

Fentanyl

Question 35

most abused narcotic drug , least to produce drug dependency

Answer 35

Meperidine (Demerol)

Question 36

mixed agonist - antagonist drug

Answer 36

Pentazocine (Talwin)