Pharmacology of heart failure Flashcards
1
Q
what are the effects of diamorphine?
A
Euphoria and sedation
Histamine release will cause vasodilation
veno and arterial vasodilation
2
Q
what are the desired therapeutic effects of diamorphine?
A
- reduce both pre and after load
- reduce distress
3
Q
what are unwanted side effects of diamorphine?
A
- respiratory depression
- hypotension
- nausea and vomit
4
Q
where do loop diuretics act?
A
On the thick ascending loop of henle on the Ka/K/Cl channel
5
Q
what are the effects of loop diuretics?
A
- promotion of water and sodium excretion
- vasodilation
- increased excretion of potassium, magnesium, calcium
6
Q
why do loop diuretics reduce preload?
A
They increase excretion of water and sodium
7
Q
what are unwanted side effects of loop diuretics?
A
- hypovolaemia and hypotension
- hypokalaemia
- hyperuricaemia
- dose related hearing loss
8
Q
how do nitrates work?
A
Act as an indirect NO donor
activatedguanylate cyclase in VSM –> cCGMP
9
Q
what are the effects of nitrates?
A
veno and vasodilation
inhibits anti-platelet aggregation
