LOBS Flashcards
what is the immediate management of heart failure?
high flow oxygen
diamorphine
furosemide
GTN spray
what is the point of giving a loop diuretic for heart failure?
Increases sodium and water excretion
reduces preload
vasodilation
what are the side effects of loop diuretics?
hypotension
hypovalaemia
dose related hearing loss
what is the neurohormonal model of heart failure?
decreased CO leads to neurohormonal activation
two pathways of neurohormonal release
1. RAAS activation leading to increased preload and vascular resistance. also leading to aldosterone release causing vasoconstriction and hypertrophy
- sympathetic activation; increased vascular resistance and after load. increased catecholamine release meaning increased workload
why do ACE inhibitors help in heart failure?
Decrease mortality and help prevent RAAS cycle in the neurohormonal model
why do beta blockers help in heart failure?
symptom relief and mortality
prevent renin release due to bet 1 receptors
decrease rate and contractility.
why does spirolactone help in heart failure?
It’s an aldosterone antagonist
increases sodium and water loss decreasing preload
helps mortality
what are causes of aortic stenosis?
- congenital in people born with a bicuspid valve
- calcification associated with smoking and hypertension
- Williams syndrome
- post rheumatic valve
what are problems seen in Williams syndrome?
aortic stenosis hernias dental issues renal issues sensitive hearing retardation low birth weight
what are clinical features of aortic stenosis?
SOB chest pain syncope ejection systolic murmur narrow pulse pressure slow rising pulse
what is the management of aortic stenosis?
observe if there are no symptoms
aortic valve replacement
transcatheter aortic valve implantation
when is an aortic stenosis patient considered for surgery?
Area <1cm
spontaneous symptoms
abnormal LV systolic function
what is aortic regurgitation?
the valve leaflets become incompliant and there is a leakage of blood into the LV during diastole
what are causes of aortic regurgitation?
- congenital due to a bicuspid valve
- aortopathy
- acquired
4 syphilis - acute
what are causes of aortopathy aortic regurg?
collagen disorderes
ehler danlos
osteogenesis imperfect