Pharmacology of Endocrinology Flashcards
1
Q
What is metyrapone used for?
A
- Control of Cushing’s syndrome prior to surgery
- Control of Cushing’s syndrome after radiotherapy
2
Q
What is the primary drug target of metyrapone?
A
- 11β-hydroxylase
- 11-deoxycortisol
3
Q
What is the drug target type of metyrapone?
A
- Enzyme antagonist
4
Q
What is the location of action of metyrapone?
A
- Zona fasciculata of the adrenal glands
5
Q
What is the mechanism of action of metyrapone?
A
- Inhibition of 11β-hydroxylase
- Inhibit cortisol
- Inhibit 11-deoxycortisol
- Inhibit corticosterone
6
Q
What are the main adverse effects of ketoconazole (1)?
A
-
Liver toxicity
- Need to monitor liver function weekly
7
Q
What is ketoconazole used for?
A
- Control of Cushing’s syndrome prior to surgery
8
Q
What is the primary drug target of ketoconazole?
A
- 17α-hydroxylase
9
Q
What is the drug target type of ketoconazole?
A
- Enzyme antagonist
10
Q
What is the location of action of ketoconazole?
A
- Adrenal glands
11
Q
What is the mechanism of action of ketoconazole?
A
- Inhibition of 17α-hydroxylase
- Inhibit cortisol
12
Q
What are the main adverse effects of metyrapone (2)?
A
- Hypertension
- Hirsutism
13
Q
What is spinolactone used for?
A
- Potassium sparing diuretic for primary hypoaldosteronism
14
Q
What is the primary drug target of spinolactone?
A
- Mineralocorticoid Receptor (MR)
15
Q
What is the drug target type of spinolactone?
A
- Receptor antagonist
17
Q
What is the mechanism of action of spinolactone?
A
- Inhibit Mineralocorticoid Receptor (MR)
- Inhibit aldosterone dependent sodium potassium exchange channels
- Increase in Na+ retention
- Increase in K+ secretion
- Increase in water secretion
