Pharmacology of Drugs related to Hypothalamic & Pituitary Hormones

Question 1

The effects of growth hormone are mediated by the production of what hormone?

Answer 1

Insulin-like growth factor 1 (IGF1)

Question 2

This drug is a purified form of FSH.

Answer 2

Urofollitropin

Question 3

What is the MOA of Pegvisomant?

Answer 3

Growth hormone receptor antagonist

Question 4

These drugs act to inhibit growth hormone release.

Answer 4

Octreotide, lanreotide

Question 5

This is a recombinant form of growth hormone.

Answer 5

Somatropin

Question 6

This drug is an ADH analog that increases cofactor VIII & vWF.

Answer 6

Vasopressin

Question 7

True/False. GnRH agonists cause an initial rise in LH & FSH release before inhibition.

Answer 7

True - LH & FSH are initially released before receptors are downregulated

Question 8

These drugs are contradicted in patients with a history of psychosis.

Answer 8

D2 agonists - cabergoline, bromocriptine

Question 9

Release of this hormone is inhibited by dopamine binding to D2 receptors.

Answer 9

Prolactin

Question 10

True/False. Mecasermin is associated with hyperglycemia.

Answer 10

False - Mecasermin is associated with hypoglycemia since it mimics the action of insulin.

Somatropin is associated with hyperglycemia.

Question 11

This drug is a recombinant form of LH.

Answer 11

Lutropin

Question 13

What is the MOA of ganirelix and degarelix?

Answer 13

GnRH antagonists

Question 14

What is the benefit of pegvisomant vs. octreotide?

Answer 14

Pegvisomant is specific to GH. Octreotide inhibits the release of GH, but also inhibits insulin, glucagon, and gastrin

Question 15

This is a recombinant form of IGF-1.

Answer 15

Mecasermin

Question 16

This drug is a mixture of FSH & LH.

Answer 16

Menotropin

Question 17

Leuprolide and goserelin are GnRH agonists. Why then do they inhibit FSH & LH release?

Answer 17

FSH & LH are only released with pulsatile stimulation from GnRH. Agonists cause continuous stimulation that downregulates receptors and inhibits release.