Pathology of the Pancreas & Diabetes-Related Pathology Flashcards
This disorder is caused by a gastrin-secreting neuroendocrine tumor.
Zollinger-Ellison Syndrome
Where are pancreatic alpha cells located?
Periphery of islets of Langerhans
A necrotizing, migratory rash is associated with this pancreatic neuroendocrine neoplasm.
Glucagonoma - other symptoms include mild hyperglycemia and anemmia
Cholelithiasis can be associated with this neuroendocrine neoplasm.
Somatostatinoma - this is due to inhibited secretion of digestive enzymes
VIPomas secrete vasoactive intestinal polypeptide. What is the function of VIP?
Induces glycogenolysis and hyperglycemia and regulates ion and water secretion in the GI tract
What organs are affected in MEN1 syndrome?
Pituitary, parathyroid, pancreas
Somatostatin is secreted by what pancreatic cells?
Delta cells
True/False. Amyloid deposition is characteristic of Type 1 diabetes.
False - amyloid deposition is only found in Type 2 diabetes
Pancreatic neuroendocrine tumors are positive for these IHC stains.
Chromogranin A, synaptophysin
What histologic changes are characteristic of type 2 diabetes?
Amyloid deposition and hyalinization
What is the pathologic progression of diabetic nephropathy?
Initial increase in GFR due to renal hypertrophy and hyperfiltration. Over time, GFR decreases and proteinuria presents. Ultimately, renal failure
What symptoms are characteristic of a VIPoma?
Watery diarrhea, hypokalemia, and achlorhydria
Insulinomas and gastrinomas are associated with what metabolic disorder?
MEN1
Symptoms of insulinomas are primarily due to what cause?
Hypoglycemia due to chronically high insulin levels
What are pancreatic beta cells mostly located?
Central region of islets of Langerhans
What immune cells are most likely to be found on histology of the pancreas of a patient with Type 1 diabetes?
Lymphocytes within islets - ultimately leads to fibrosis and atrophy
