Pharmacology of Arthritis Flashcards
What are the main clinical side effects of NSAIDs?
GI dysfunction Renal impairment Increased CV risk Fluid retention Wheeze Rash
Which new drug is used as an alternative to NSAIDs?
Cox-2 inhibitors
What are the main clinical side effects of methotrexate?
Teratogenic Leucopaenia/ thrombocytopaenia Hepatitis/ cirrhosis Pneumonitis Rash/ mouth ulcers Nausea Diarrhoea
How long before conception should DMARDs be stopped?
3 months
What are the main clinical side effects of leflunomide?
Hepatotoxicity
Hypertension
Teratogenic
What are the main clinical side effects of sulfasaline?
Low sperm count
Insomnia
Depression
Yellow body fluids
What is the main clinical side effect of hydroxychloroquine?
Irreversible retinopathy
Which DMARDs are safe to use in pregnancy?
Sulfasaline
HCQ
What are the main clinical side effects of biological agents?
Risk of infection especially TB
Malignancy risk?
CI in pulmonary fibrosis, HF
What type of drug is allopurinol?
Xanthine oxidase inhibitor (stops purine being converted into uric acid)
What are the main clinical side effects of allopurinol?
Rash
Renal disease
Bone marrow aplasia
What are alternative medications that can be prescribed in the prophylaxis of gout?
Febuxostat
Uricosurics
List the main clinical side effects of steroids
Weight gain Muscle wasting Skin atrophy Osteoporosis DM Hypertension Cataracts/ glaucoma Fluid retention Adrenal suppresion |mmunosuppression AVN of femoral head
What is the main clinical consideration for prescribing steroids in the elderly?
Osteoporosis prophylaxis
