Pharmacology of anxiolytics Flashcards
1
Q
Drugs used to treat anxiety?
A
Barbiturates BZD Antidepressants Buspirone Pregablin B Blockers eh propanolol
2
Q
What is the molecular action of BZDs?
A
Act by increasing GABA mediated inhibition
3
Q
Effects of BZDs?
A
Reduce anxiety and aggression
Hypnosis/sedation
Muscle relaxation
Anticonvulsant use
Anterograde amnesia
4
Q
What effect does GABA have on target cells?
A
Causes hyperpolarisation
5
Q
Problems with BZDs?
A
Tolerance and dependance
Paradoxical aggression
Anterograde amnesia and impaired coordination
6
Q
Symptoms of BZD withdrawal?
A
Confusion, toxic psychosis, convulsions, anxiety, insomnia etc etc
7
Q
Which drug is used in social anxiety disorder?
A
Moclobemide
8
Q
Method of action o Pregablin?
A
Ca2- channel blocker, GABA enhancer- only used if unresponsive to other treatments
9
Q
What class of drug is Buspirone?
A
5-HT receptor partial agonist
