pharmacology need to know Flashcards
what antibiotic is prescribed for ANUG and its dose/duration?
metronidazole
400mg 3x per day for 3 days
what is the specific advice given for metronidazole?
no alcohol
interaction with warfarin
what drugs can cause xerostomia?
tricyclics
anticholinergic
benzodiazepines
diuretics
opioid
nicotine
what are the 3 types of antifungal therapy?
echinocandins
azoles- fluconazole
polyenes
give an example of an azole (antifungal medication)
fluconazole
give an example of a polyene (antifungal medication)
nystatin
give an example of an echinocandin (antifungal medication)
micofungin
what is the drug action of flucanazole?
interupts conversion of lanosterol to ergosterol by interacting with the enzyme which catalyses the conversion which stops formation of fungal membrane
what is the drug action of nystatin?
binds to sterols in plasma membrane of fungi, causing cells to leak
this causes fungal cell death
what is the mechanism of apixaban?
a selective inhibitor of FXa
does not require antithrombin III for antithrombic activity
inhibits free and clot-bound FXa and prothrombinase activity
has no direct affect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin
decreases thrombin generation and thrombus development
how long before a procedure is AB prophylaxis taken and what guidance is this from
1 hour
SDCEP guidance
What is the antibiotic and dose given for antibiotic prophylaxis
amoxicillan 3g
clyndamicin 600mg
What are contraindications for fluconazole or metronidazole?
statins
patients taking warfarin
What is an alternative to giveng fluconozol if the patient is taking statins?
nystatin
Why can chemotherapy affect cells in the mouth?
chemotherapy affects cells with a high turnover.
Mucosa has a high turnover of cells and affects from chemo can lead to poor wound healing and oral mucositis
