Pharmacology: Miscellaneous

Question 1

MoA azole anti-fungals

Answer 1

they compete with CP450 which is a key enzyme in fungal ergosterol synthesis. Accumulation of methylated sterols in the cell results in weakening of the cell membrane and increased cell permeability.

Question 2

MoA griseofulvin

Answer 2

Inhibition of fungal mitotic spindle formation

Question 3

Terbinafine MoA

Answer 3

Also inhibits ergesterol synsthesis via blcoking of squalene monoxygenase

Question 4

MoA Amphotericin B

Answer 4

Binds membrane sterols, altering membrane permeability.

Question 5

Should anti-fungal agents be given with food? Why?

Answer 5

They need to be given with a meal to stimulate gastric acid release so that they can be better absorbed.

Question 6

Which anti-fungals have a greater effect on steroid synthesis?

Answer 6

Imidazoles:

• Ketoconazole
• clotrimazole
• Enilconazole
• Miconazole

Question 7

What is the main concern/side effect with using amphotericin B?

Answer 7

It has a high risk of causing AKI