Pharmacology: DPP4 inhibitors Flashcards
what is the mechanism of DPP4
it breaks down and inactivates peptides, such as GLP-1 and GIP
what result do DPP4 inhibitors gave on the incretin effect
inhibit DPP4 breakdown of GLP-1 and GIP, therefore increased incretin effect
what effect do DPP4 inhibitors have on insulin secretion
increase insulin secretion
what type of drugs are DPP4 inhibitors
insulin secretagogues
do DPP4 inhibitors cause hypoglycaemia
no, because incretin action is glucose dependant
how potent are DPP4 inhibitors
not very, only reduce HbA1c by5-8mmol/ml
what effect do DPP4 inhibitors have on weight
weight neutral
what is the most often used DPP4 inhibitor
Sitagliptin, 100mg od
describe the side effects of DPP4 inhibitors
minimal, generally very well tolerated(liked by patients), but in around 1 in 1000 increased risk of pancreatitis
