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FRCR 1a - Stuff > Pharmacology basics > Flashcards

Pharmacology basics Flashcards

1
Q

Carbamazepine (p450)

A

P450 inducer

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2
Q

Rifampicin (p450)

A

P450 inducer

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3
Q

Alcohol (p450)

A

Both

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4
Q

Phenytoin (p450)

A

P450 inducer

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5
Q

Griseofulvin (p450)

A

P450 inducer

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6
Q

Phenobarbitone (p450)

A

P450 inducer

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7
Q

Sulfonylurea (p450)

A

P450 inducer

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8
Q

Sodium valproate (p450)

A

P450 inhibitor

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9
Q

Cimetidine (p450)

A

P450 inhibitor

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10
Q

Isoniazid (p450)

A

P450 inhibitor

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11
Q

Ketoconazole (p450)

A

P450 inhibitor

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12
Q

Fluconazole (p450)

A

P450 inhibitor

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13
Q

Chloramphenicol (p450)

A

P450 inhibitor

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14
Q

Erythromycin (p450)

A

P450 inhibitor

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15
Q

Sulfonamides (p450)

A

P450 inhibitor

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16
Q

Ciprofloxacin (p450)

A

P450 inhibitor

17
Q

Omeprazole (p450)

A

P450 inhibitor

18
Q

Metronidazole (p450)

A

P450 inhibitor

19
Q

Which chemotherapy are associated with a
higher risk of acute hypersensitivity reactions?

A

Taxanes (Paclitaxel/Docetaxel)
Platinum compounds (Cisplatin/Carboplatin/Oxaliplatin)
Doxorubicin
Teniposide

20
Q

Which monoclonal antibodies are associated with a
higher risk of acute hypersensitivity reactions?

A

Trastuzumab
Rituximab
Cetuximab
Bevacizumab

21
Q

What non-cancer drugs prolong the QT interval?

A

T - Thiazides
O - Olanzapine
O - Opioids
R - Risperidone (Typical and atypical antipsychotics)
S - Ciprofloxacin
A - Antihistaminics
D - antiDepressants like TCAs and SSRIs
E - Erythromycin (Macrolide antibiotics)

22
Q

What drugs are radio-sensitising?

A

“Daring Cats Chase Big Trains Past Calm Oceans, Ignoring Storms”
* D: Dabrafenib (BRAF inhibitor)
* C: Cetuximab (EGFR inhibitor)
* C: Crizotinib (ALK inhibitor)
* B: Bevacizumab (VEGF inhibitor)
* T: Trametinib (MEK inhibitor)
* P: Palbociclib (CDK 4/6 inhibitor)
* C: Cetuximab (EGFR inhibitor)
* O: Osimertinib (ALK inhibitor)
* I: Ipilimumab (Immunotherapy)
* S: Sunitinib (VEGF inhibitor)

23
Q

Drugs that cause hand-foot syndrome (9)

A

‘Cats & Dogs Epically Do Surprises, Cats Dance Triumphantly!’

Capecitabine
5-Fluorouracil
Doxorubicin
Epirubicin
Docetaxel
Sunitinib
Cabozaninib
Dabrafenib
Trametinib

FRCR 1a - Stuff (3 decks)

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