Pharmacology - Antivirals

Question 1

Aciclovir

Answer 1

DNA polymerase inhibitor. aciclovir triphosphate competitively inhibits viral DNA polymerase

Question 2

Amantadine

Answer 2

Viral ion channel disruptor. Can also be used in Parkinson’s disease.
inhibits ion channel which is needed to uncoat the virus once it’s inside the cell.

Question 3

Amprenavir

Answer 3

Protease Inhibitor. used to treat HIV-1.

Question 4

Zidovudine

Answer 4

Thymidine analogue. Nucleoside reverse transcriptase inhibitor (NRTI) used to treat HIV-1. inhibits reverse transcriptase

Question 5

Doravirine, nevirapine, efavirenz, etravirine, rilpivirine

Answer 5

non-nucleoside reverse transcriptase inhibitors (NNRTIs). Alter reverse transcriptase

Question 6

Enfuvirtide

Answer 6

fusion inhibitor. blocks HIV from entering CD4 cells

Question 7

What types of drugs usually make up an HIV drug regimen?

Answer 7

2 nucloside reverse transcriptase inhibitors (NRTIs) and either an NNRTI or PI.

Question 8

What does HAART stand for?

Answer 8

Highly active anti-retroviral therapy

Question 9

What types of drugs are used in PEP ?

Answer 9

2 NRTIs and a PI

Question 10

What types of drugs are used in PrEP?

Answer 10

2 NRTIs