Pharmacology - Antiviral Agents

Question 1

What is the general action of adamantine?

Answer 1

Inhibitor of viral uncoating

Question 2

What virus does adamantine work against?

Answer 2

Influenza A

Question 3

What is the mechanism of action of adamantine?

Answer 3

Inhibit influx of proteins through M2

Question 4

What group is used instead of adamantine?

Answer 4

Rimantadine

Question 5

What is the mechanism of neuroamidase inhibitor action?

Answer 5

Neuroamidase is needed to cleave sialic acid from membrane to allow virus to release

Question 6

How is zanamavir given and why?

Answer 6

Administered by inhaler because it has poor oral bioavailability

Question 7

What diseases is oseltamavir given for prophylactically?

Answer 7

H5N1 avian influenza (bird flu)

Flu cases in susceptible populations

Question 8

What is ribavirin used for?

Answer 8

RSV

Hep C

Question 9

How is ribavirin administered?

Answer 9

Aerosole form

Question 10

What is palivizumab used for?

Answer 10

RSV infections in high risk children