pharmacology and prescribing Flashcards
how are medications in the UK licensed?
MHRA - medicines and healthcare products regulatory agency
EMA - European medicines agency
name a process by which medicines are ensured to be of high standards of safety and quality?
SMC submission - Scottish Medicines Consortium
what is off-label medication?
licensed medication which is used for unlicensed indication
what are special medications?
unlicensed dermatological preparations
these tend to have a long history of use which is clinically effective, despite having no strong evidence base
name 4 reasons for prescription errors?
lack of knowledge - about patient, meds, allergies etc.
poor communication
mistake writing/ generating prescription
no local/ national guidelines
differentiate between pharmacokinetics and pharmacodynamics?
pharmacokinetics - effect of body on drug
pharmacoDynamics - effect of Drug on body
3 factors associated with pharmacokinetics?
distribution - where drug goes
metabolism - esp. liver disease
excretion - esp. renal disease
key factor affecting pharmacokinetics?
route of administration
optimal absorption is key - topical is often best
3 things to think about with pharmacodynamics?
age of patient
risk of pregnancy
drug interactions
4 factors associated with poor concordance to medication?
psychiatric co-morbidities
multiple applications per day
lack of patient education
unintentional non-adherence
2 components that combine to make a topical therapy?
vehicle + active drug
what is a vehicle?
pharmacologically inert, physically and chemically stable substance that carries the active drug
5 factors affecting absorption?
concentration of drug
base/vehicle used
thickness and hydration of stratum corneum
temperature
skin site
4 examples of vehicle?
solution
cream
gel
lotion
4 examples of topical drugs?
corticosteroid
anti-inflammatory
antibiotic
salicylic acid
topical steroids have anti-inflammatory and immunosuppressive properties - name 4 ways this is demonstrated?
regulation of pro inflammatory cytokines
vasoconstriction
suppress fibroblast, endothelial, leukocyte function
inhibition of vascular permeability