pharmacology and prescribing Flashcards

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1
Q

how are medications in the UK licensed?

A

MHRA - medicines and healthcare products regulatory agency

EMA - European medicines agency

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2
Q

name a process by which medicines are ensured to be of high standards of safety and quality?

A

SMC submission - Scottish Medicines Consortium

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3
Q

what is off-label medication?

A

licensed medication which is used for unlicensed indication

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4
Q

what are special medications?

A

unlicensed dermatological preparations

these tend to have a long history of use which is clinically effective, despite having no strong evidence base

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5
Q

name 4 reasons for prescription errors?

A

lack of knowledge - about patient, meds, allergies etc.

poor communication

mistake writing/ generating prescription

no local/ national guidelines

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6
Q

differentiate between pharmacokinetics and pharmacodynamics?

A

pharmacokinetics - effect of body on drug

pharmacoDynamics - effect of Drug on body

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7
Q

3 factors associated with pharmacokinetics?

A

distribution - where drug goes

metabolism - esp. liver disease

excretion - esp. renal disease

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8
Q

key factor affecting pharmacokinetics?

A

route of administration

optimal absorption is key - topical is often best

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9
Q

3 things to think about with pharmacodynamics?

A

age of patient
risk of pregnancy
drug interactions

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10
Q

4 factors associated with poor concordance to medication?

A

psychiatric co-morbidities

multiple applications per day

lack of patient education

unintentional non-adherence

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11
Q

2 components that combine to make a topical therapy?

A

vehicle + active drug

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12
Q

what is a vehicle?

A

pharmacologically inert, physically and chemically stable substance that carries the active drug

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13
Q

5 factors affecting absorption?

A

concentration of drug

base/vehicle used

thickness and hydration of stratum corneum

temperature

skin site

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14
Q

4 examples of vehicle?

A

solution
cream
gel
lotion

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15
Q

4 examples of topical drugs?

A

corticosteroid
anti-inflammatory
antibiotic
salicylic acid

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16
Q

topical steroids have anti-inflammatory and immunosuppressive properties - name 4 ways this is demonstrated?

A

regulation of pro inflammatory cytokines

vasoconstriction

suppress fibroblast, endothelial, leukocyte function

inhibition of vascular permeability

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17
Q

how much is a finger tip unit?

A

~0.5g

18
Q

what size of area should a finger tip unit cover?

A

an area that is double the size of one hand

19
Q

name 5 side effects of topical steroids?

A
thinning of skin 
striae 
bruising 
hirsutism 
glaucoma
20
Q

which 3 classes of medication are used as systemic treatments?

A

retinoids
Immunosuppressants
biologics

21
Q

what are retinoids and what are their function?

A

vitamin A analogues

normalise keratinocyte function
anti-inflammatory and anti-cancer effects

22
Q

which retinoid, taken orally, is commonly used to treat acne?

A

Isotretinoin

23
Q

which retinoid, taken orally, is commonly used to treat psoriasis?

A

Acitretin

24
Q

which retinoid, taken orally, is commonly used to treat cutaneous T cell lymphoma?

A

Bexarotene

25
Q

which retinoid, taken orally, is commonly used to treat hand eczema?

A

Alitretinoin

26
Q

name 2 common side effects of retinoids?

A

cheilitis (dry lips)

xerosis (dry skin)

27
Q

rarer side effects of retinoids?

A

psychiatric, eye, bone side effects

28
Q

what are immunosuppressants used to treat?

A

inflammatory skin disorders

29
Q

5 examples of immunosuppressants?

A
oral steroids 
azathioprine 
ciclosporin 
methotrexate 
mycophenolate mofetil
30
Q

2 major risks with immunosuppressants?

A

malignancy

serious infections

31
Q

what must be regularly carried out for patients using immunosuppressants?

A

regular blood test monitoring - especially:
FBC
Renal function
liver function

32
Q

when is it particularly important to monitor FBC?

A

methotrexate and azathioprine

33
Q

when is it particularly important to monitor renal function?

A

ciclosporin

34
Q

when is it particularly important to monitor liver function?

A

methotrexate

35
Q

name 1 advantage and 1 disadvantage to biologics?

A

adv - very effective, due to specific inhibition of components of immune system

dis - very costly

36
Q

what does suffix -mab denote?

A

monoclonal antibodies

37
Q

name 3 risks of infection associated with the use of biologics?

A

TB reactivation
serious infection
avoid live vaccines

38
Q

name another risk associated with the use of biologics?

A

malignancy

39
Q

name a risk associated with the use of TNF inhibitors?

A

risk of demyelination

40
Q

name 2 targeted treatments for melanoma?

A

if BRAF 600 mutation -

vemurafenib
dabrafenib

41
Q

name 2 immunotherapies for melanoma?

A

ipilimumab

pembrolizumab