Pharmacology and kidney excretion

Question 1

What is first order kinetics?

Answer 1

rate of elimination is directly proportional to drug concentration

Question 2

What is clearance?

Answer 2

the constant rate of elimination

Question 3

What does CI determine?

Answer 3

maintenance dose rate

Question 4

What is the loading dose?

Answer 4

Initially higher dose of a drug given at the beginning of a course of treatment

Question 5

Purpose of a loading dose?

Answer 5

decrease time to steady state for drugs with long half lives

Question 6

What is zero order kinetics?

Answer 6

few drugs initially eliminated at a constant rate rather than a rate proportional to their concentration

Question 7

Organ responsible for elimination of drugs

Answer 7

kidney

Question 8

What happens to drugs before being excreted by the kidneys?

Answer 8

drugs are metabolised to more polar compounds

Question 9

What happens during drug metabolism?

Answer 9

a drug is made more hydrophilic

Question 10

How are drugs eliminated in the urine?

Answer 10

glomerular filtration

Question 11

What does glomerular filtration rate show?

Answer 11

how well kidneys are working

Question 12

What does glomerular filtration estimate?

Answer 12

how much blood passes through the glomeruli every minute

Question 13

What is the normal rate of GFR?

Answer 13

90mls/min