Pharmacology and friends Flashcards
1
Q
What are the Sx of neuroleptic malignant syndrome? (Name 4)
A
rigidity, myoglobinemia, autonomic instability, fever
2
Q
What receptor do all typical anti-psychotics act on? What is the intracellular effect?
A
Block D2-receptors to raise cAMP.
3
Q
What are the typical anti-psychotics (neuroleptics)?
A
Haloperidol and the “-azines”
4
Q
Name the atypical anti-psychotics, please.
A
It's atypical for OLd CLOZets to QUIETly RISPER about ARI and ZIPpy. Olanzapine Clozapine Quetiapine Risperidone Aripiprazole Ziprasidone
5
Q
Which atypical antipsychotic can cause agranulocytosis and requires weekly CBCs?
A
Clozapine
(Watch clozapine CLOZely!
6
Q
Where are the serotonergic neurons of the CNS located?
A
Raphe nuclei of the brainstem
7
Q
What neurotransmitter is concentrated in the locus ceruleus and where is it located?
A
NE, dorsal pons
