3 Flashcards
gamma-glutamyl transferase (GGT) is a sensitive indicator of _______?
alcohol use
Where is the mu receptor located?
On the presynaptic neuron (bouton).
What kind of a receptor is the mu opiate receptor? What is the effect of its binding?
Gi-proteic-coupled receptor; prevents release of excitatory neurotransmitters.
What are the main excitatory neurotransmitterrs whose release is inhibited by opiates?
Glutamate, NE, Epi, and serotonin.
What are the main features of Delirium Tremens (DT)?
“Autonomic storm”, confusion, hallucinations
What are the autonomic features of DT?
anxiety, tremors, tachycardia, seizures
The term “cold turkey” comes from opiate withdrawal. Why?
piloerection
Caffeine acts as a competitive _______ of _______.
inhibitor, adenosine
What is suboxone?
Oral Tx for heroin withdrawal. Contains Buprenorphine (partial μ-agonist) + Noloxone (μ-antagonist when taken IV).
What is the classic triad of Wernicke’s encephalopathy?
confusion, ataxia, and ophthalmoplegia
What are the features of Korsakoff psychosis?
confabulations, personality change, irreversible memory loss
Tx for Delirium Tremens?
benzos
