Pharmacology Flashcards

1
Q

Signs of Digitalis Toxicity

A

N/V, drowsiness, SVT, AV block, sinus bradycardia

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2
Q

What increased digoxin toxicity?

A

Hypokalemia, hypocalcemia, renal disease, hypoxia

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3
Q

What do ACE inhibitors do to hemodynamics?

A

Reduce afterload and attenuate neurohormonal effects of heart failure. Do not use in HCOM or Aortic stenosis

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4
Q

Advair

A

Fluticasone/Salmetarol - dose 100/50, 250/50, 500/50

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5
Q

Flovent

A

fluticasone Diskus: 50mcg, 100mcg, 250mcg

HFA: 44, 110, 220mcg

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6
Q

Omalizumab

A

Selective anti-immunoglobulin E therapy - humanised monoclonal antibody against IGe. Subq injection every 2-4 weeks. Indicated for pts>12 with steroid dependent asthma and allergies confirmed by skin testing.

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7
Q

Dose of zantac IV for peds

A

0.1mg/kg/d IV

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8
Q

What effects does methotrexate have when taken in pregnancy?

A

When taken between weeks 6-9 causes increased risk of craniosynotosis, craniofacial abnormalities, limb defects

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9
Q

What can use of ACE inhibitors during pregnancy cause?

A

renal dysgenesis, oligohydramnios, skull ossification defects

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10
Q

What does use of phenytoin during 1st trimester cause?

A

10% risk of fetal hydantoin syndrome - growth deficiency, devo delay, craniofacial abnormalities, hypoplastic phalanges/nails, also can have vitamin K deficiency

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11
Q

What effects do retinoic acid cause in utero?

A

Similar to DiGeorge syndrome

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12
Q

What effect does tetracycline have in utero?

A

increased risk of spina bifida and craniofacial defects

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13
Q

What effects does warfarin have in utero?

A

nasal hypoplasia and stipple epiphyses

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14
Q

What effects can Mercury have on the fetus?

A

cerebral atrophy, seizures, and devo delay

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15
Q
A
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