Pharmacology

Question 1

Dihydropyridine

Non-dihydropyridine

Answer 1

Dihydropyridine = l-type ca channel
- more vasodilation, less cardiac
- amlodipine, nicardipine
non-dihydropyridine = l-type ca channels
- more cardiac, less vasodilation
- verapamil (phenylalkylamine), diltiazem (benzothiazepine)

Question 2

Diuretic resistance 8 causes

Answer 2

• Distal tubular hypertrophy
• Braking phenomenon
• RAAS, SNS and ADH upregulation
• Acidosis competes with OATs
• Hypoproteinemia
• CHF or CKD decrease renal blood flow
• Gut wall edema decrease oral absorption
• NSAIDS
• High sodium diet

Question 3

Name 3 class 1a antiarrhythmics

Answer 3

Quinidine, procainamide, disopyramide.

Question 4

Mechanism of digitalis-induced arrhythmias

Answer 4

DADs

Question 5

Effect of na ch blockers class 1a on av node conduction?

Answer 5

Increases - vagolytic