Acquired

Question 1

3 mechanisms of action of thyroid hormones

Answer 1

Nuclear receptors -> protein synthesis
Altered response to SNS (increased)
Peripheral effect on Na/K/Atpase and Ca/atpase (increased activity)

Question 2

Catecholamine toxicity.
Which condition is this associated with?
What are the mechamisms?
What is the characteristic histopath lesion?

Answer 2

1. Pheochromocytoma
2. Hypoxia
   Microcirculation changes
   Oxidative damage
   Secondary remodeling due to systemic hypertension
3. Contraction band necrosis

Question 3

What is accumulating in the valve in DMVD?

Which valve layer becomes myxomatous?

Answer 3

Glycosaminoglycans and proteoglycans, + connective tissue derangements
Spongiosa