Genetics Flashcards
4 types of modes of transmission
Autosomal dominant: with only one copy of the gene the mutation will show
Autosomal recessive: trait will not be displayed unless both copies of the mutation are present
X-linked: associated with X chromosome, males always show trait because only 1 X chromosome, females may be silent carriers unless both of their X chromosome carries gene
Polygenic: 2 or more genes
Penetrance vs expressivity
Penetrance: less than 100% of affected animals will demonstrate the trait
Expressivity: Spectrum of phenotypic expression with different severity
Endomyocardial fibrosis
Burmese and Siamese
ASD (2 breeds)
Standard Poodle (suspect autosomal dominant)
Doberman (MOI unknown)
Other breeds: Boxers and Samoyeds
*Ostium secundum defects
PDA
Poodles - polygenic
PS
Beagle - polygenic
Bulldog - autosomal recessive
SAS - proven
Newfoundland - PICALM gene - autosomal dominant
Phosphatidylinositol-binding clathrin assembly protein
-> PICALM is important in outflow tract development
SAS breeds
Newfoundland (AD), Boxer, GSD, Rottweilers (AR), Golden (AR), Bullmastiffs (AR)
AR: autosomal recessive
Dogue de Bordeaux
SAS and TVD
In Israel
Suspect autosomal recessive
TOF
Keeshond - polygenic (3 chromosomes)
TVD
Labrador
Autosomal dominant with reduced penetrance
Area on Chromosome 9
VSD
Beagle (autosomal recessive) and English Springer Spaniel (autosomal dominant with incomplete penetrance)
Unproven: Lakeland terrier, WHWT, basset hounds
Polygenic
PDA in Poodles, PS in Beagles, TOF in Keeshonds
Autosomal dominant
TVD in labs, VSD in ESS, SAS in Newfy, ASD in Poodles
Autosomal recessive
VSD in Beagles, TVD and SAS in Dogue de Bordeaux
PS bulldogs
