Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

nursing > Pharmacology > Flashcards

Pharmacology Flashcards

You may prefer our related Brainscape-certified flashcards:
Family Nurse Practitioner (FNP) flashcards NCLEX-PN® flashcards
1
Q

Pharmacology

A

The study of biological effects of chemicals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pharmacotherapeutics

A

clinical pharmacology, the branch of pharmacology that uses drugs to treat, prevent, and diagnose disease.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pharmacokinetics

A

how the body acts on the drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Absorption

A

what happens to a drug from the time it enters the body until it enters the circulating fluid; intravenous administration causes the drug to directly enter the circulating blood, bypassing the many complications of absorption from other routes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

pharmacodynamics

A

the study of the interactions between the chemical components of living systems and the foreign chemicals, including drugs, that enter living organisms; the way a drug affects a body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Distribution

A

movement of a drug to body tissues; the places where a drug may be distributed depend on the drug’s solubil- ity, perfusion of the area, cardiac output, and binding of the drug to plasma proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Pharmacogenomics

A

the study of genetically determined variations in the response to drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

first pass effect

A

a phenomenon in which drugs given orally are carried directly to the liver after absorption, where they may be largely inactivated by liver enzymes before they can enter the general circulation; oral drugs frequently are given in higher doses than drugs given by other routes because of this early breakdown

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

critical concentration

A

the concentration a drug must reach in the tissues that respond to the particular drug to cause the desired therapeutic effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

4 usual drug fxn.’s

A
  1. Replace missing chemical. 2. Increase or stimulate cellular activity (agonist). 3. Decrease or repress cellular activity (antagonist). 4. Interfere with cellular activity of foreign cells (chemotherapeutic effect) (antibiotics)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

agonists

A

Directly interact with receptor sites to cause the same activity that natural chemicals would cause at that site. eg: Insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Antagonist

A

act to prevent the breakdown of natural chemicals that are stimulating the receptor site. eg: MAO inhibitors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Selective Toxicity

A

The ability of a drug to attack only those systems found in foreign cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Alpha1 receptor

A

Vasoconstriction, increased peripheral vascular resistance=^BP, contracted pilorection muscles, thickened saliva, male sexual emission, pupil dilation, closed urinary sphincter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Alpha2

A

Prevents overstimulation of effector. Sites. Moderates insulin release by beta cells of pancreas.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Beta1

A

^ heart acticvity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Beta2

A

Vasodilation

Brochodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Location of alpha 1

A

Iris, blood vessels, urinary bladder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Location of alpha2

A

On nerve membranes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Beta1

A

Cardiac tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Beta2

A

Smooth muscle of blood vessels, bronchi, in periphery and in uterine muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Sympathomimetic drugs

A

Adrenergic agonist
Mimics the effects of the SNS
Treatments for shock, ophthalmic solution to dilate pupil, asthma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Dopamine indications

A

Correction of hemodynamic imbalances present in shock.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Alpha and beta adrenergic agonists

A

Dobutamine treatment of HF
Ephedrine treats hypotension
Epinephrine treat shock bronchospasm prolong vasoconstriction for anesthesia
Norepinephrine treat shock cardiac arrest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Alpha specific adrenergic agonists

A

Clonidine treats essential hypertension, chronic pain, opiate withdrawal
Midodrine treats orthostatic BP
Phenylephrine cold/allergy glaucoma potent vasoconstictor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Labetalol indications/uses

A

Hypertension, control of BP with pheochroocytoma. Clonidine withdrawal.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Labetalol actions

A

Competitively blocks alpha and beta receptors in SNS. Causes >BP without reflex tachycardia and >renin levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Labetalol adverse effects

A

Dizziness, vertigo, fatigue, gastric pain, fart, impotence, bronchospasm, dyspnea, cough, >exercise tolerance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

contraindications for labetalol and other non specific adrenergic blockers

A

Bradycardia, heart blockages, asthma, bronchospasm, shock or HF, diabetes, preg/lact

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Pheochromocytoma

A

a tumor of the chromaffin cells of the adrenal medulla that releases norepinephrine and epinephrine. Causes Hypertension and tachycardia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Dopamine Actions

A

Acts directly Increasing HR, BP stimulates SNS response. Releases norepinephrine from sympathetic nerve terminals; mediates dilation of vessels in the renal and splanchnic beds to maintain renal perfusion. Protecting kidney.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Dopamine Adverse effects

A

Tachycardia, ectopic beats, anginal pain, hypotension, dyspnea, nausea, vomiting, headache.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Teaching points of non-specific adrenergic blockers

A
  • discontinue herbal/otc drugs that interact ie: gensing, sage, xuan shen, nightshade etc.
  • Don’t abrubtly stop taking (2 wk. wean)
  • slow movements such as standing and sitting.
  • cautions with driving/machinery.
34
Q

Drug reactions with non-specific adrenergic blockers

A

risk of hypotension if combined with volatile liquid general anesthetics eg: enflurane, halothane, or isoflurane. The effectiveness of diabetic agents is increased, leading to hypoglycemia. carvedilol-conduction system disturbances when combined with verapamil or diltiazem.

35
Q

phentolamine

A

NONSELECTIVE ALPHA-ADRENERGIC BLOCKING AGENT: The only one still in use.

36
Q

phentolamine indications

A

Prevention/control of hypertensive episodes associated with pheochromocytoma; test for diagnosis of pheochromocytoma; prevention and treatment of dermal necrosis and sloughing associated with IV extravasation of norepinephrine or dopamine.

37
Q

phentolamine Actions

A

Competitively blocks postsynaptic alpha1- and presynaptic alpha2-receptors, causing a vasodilation and lowering of blood pressure, accompanied by increased reflex tachycardia.

38
Q

Phentolamine Contraindications

A

CAD, MI, Cautions: Preg/Lact.

39
Q

Phentolamine Adverse effects

A

Acute and prolonged hypotensive episodes, MI, tachycardia, arrhythmias, nausea, flushing.

40
Q

The alpha1-selective adrenergic blocking agents contraindications (Doxazosin or Prazosin)

A

used cautiously with HF or renal failure because of blood pressure–lowering effects. Hepatic impairment could alter the metabolism. Allegy, Preg/Lact.

41
Q

The alpha1-selective adrenergic blocking agents indications Doxazosin

A

Treatment of mild to moderate hypertension as monotherapy or in combination with other antihypertensives; treatment of benign prostatic hypertrophy.

42
Q

Doxasozin Actions

A

Reduces total peripheral resistance through alpha blockade; does not affect heart rate or cardiac output; increases high-density lipoproteins while lowering total cholesterol levels.
*relaxation of the bladder and prostate and improved flow of urine in male patients

43
Q

Doxasozin Adverse effects

A

Headache, fatigue, dizziness, postural dizziness, vertigo, tachycardia, edema, nausea, dyspepsia, diarrhea, sexual dysfunction.

44
Q

The alpha1-selective adrenergic blocking agents Drug Interactions ( Doxazosin)

A

hypotensive effects may occur if these drugs are combined with any other vasodilating or antihyper- tensive drugs, such as nitrates, calcium-channel blockers, and angiotensin-converting-enzyme inhibitors.

45
Q

NONSELECTIVE BETA-ADRENERGIC BLOCKING AGENTS (Propanolol) Indications

A

Widely Used to treat CV problems and to prevent reinfarction after MI. Hypertension, angina pectoris, idiopathic hypertrophic subaortic stenosis, supraventricular tachycardia, tremor; adjunctive therapy in pheochromocytoma; prophylaxis of migraine headache; management of situational anxiety.

46
Q

Action of NONSELECTIVE BETA-ADRENERGIC BLOCKING AGENTS (Propanolol)

A

Competitively blocks beta-adrenergic receptors in the heart and juxtaglomerular apparatus; reduces vascular tone in the central nervous system.
>HR, contractility, and excitability, as well as a membrane-stabilizing effect, lead to a decrease in arrhythmias, a decreased cardiac workload, and decreased oxygen consumption. The juxtaglo- merular cells are not stimulated to release renin contributing to >BP.

47
Q

Adverse effects of NONSELECTIVE BETA-ADRENERGIC BLOCKING AGENTS (Propanolol)

A

Allergic reaction, bradycardia, HF, cardiac arrhythmias, CVA, pulmonary edema, gastric pain, Fart, impotence, decreased exercise tolerance, bronchospasm.

48
Q

contraindications of NONSELECTIVE BETA-ADRENERGIC BLOCKING AGENTS (Propanolol)

A

bradycardia, heart blocks, shock, or HF, which could be exacerbated by the cardiac-suppressing effects; with bronchospasm, ; CAUTION: diabetes and hypoglycemia because blocking of the normal signs and symptoms of hypoglycemia and hyperglycemia; with thyrotoxicosis because of the adrenergic blocking effects on the thyroid gland; or with renal or hepatic dysfunction, which could interfere with the excretion and metabolism of these drugs.
Caution COPD, or acute asthma, which could worsen due to the blocking of the sympathetic bronchodilation

49
Q

Drug Interactions of NONSELECTIVE BETA-ADRENERGIC BLOCKING AGENTS (Propanolol)

A
  • paradoxical hypertension occurs when beta- blockers are given with clonidine, and increased clonidine withdrawal may also occur.
  • decreased antihypertensive effect occurs if beta- blockers are given with NSAIDs
  • initial hypertensive episode followed by bradycardia with epinephrine.
  • Peripheral ischemia beta-blockers with ergot alkaloids.
  • With insulin or other anti-diabetic agents, there is a potential for change in blood glucose levels. And a Masked symptom effect.
50
Q

Indications of Beta1-selective adrenergic blocking agents (atenolol)

A

Beta1-selective adrenergic blocking agents do not block the beta1-receptors that are responsible for bronchodilation and therefore are preferred in patients with respiratory problems. ■ Beta1-selective adrenergic blocking agents treat hypertension and angina, HF, MI; off-label uses are prevention of migraine headaches, alcohol withdrawal syndrome, and supraventricular tachycardias.

51
Q

Adverse effects of Beta1-selective adrenergic blocking agents (atenolol)

A

Allergy, dizziness, sleep disturbances, memory loss, and disorientation. bradycardia,HF, arrhythmias, gastric pain, Fart, impotence, dysuria, bronchospasm, decreased exercise tolerance.

52
Q

Contraindications of Beta1-selective adrenergic blocking agents (atenolol)

A

Allergy, sinus bradycardia, heart block, cardiogenic shock, HF, or hypotension, Preg/Lact. CAUTION: diabetes, thyroid disease, or COPD.

53
Q

Drug Interactions with Beta1-selective adrenergic blocking agents (atenolol)

A
  • decreased hypertensive effect occurs if these drugs are given with clonidine, NSAIDs, rifampin, or barbiturates.
  • initial hypertensive episode followed by bradycardia if these drugs are given with epinephrine.
  • Increased serum level and toxicity of IV lidocaine. *risk for orthostatic hypotension with prazosin.
  • increased effects if taken with verapamil, cimetidine, methimazole, or propylthiouracil
54
Q

Adrenergic Blocking or Sympatholytic drugs

A

*lyse, or block, the effects of the SNS
*Therapeutic and adverse effects
Related to their ability to react with specific adrenergic receptor sites without activating them
*Action-
Prevent norepinephrine from activating the receptor

55
Q

Carvedilol (Coreg)

A

hypertension and congestive heart failure (adult)

56
Q

Guanadrel (Hylorel):

A

hypertension in adults not responding to thiazide diuretics

57
Q

Guanethidine (Ismelin):

A

hypertension and renal hypertension

58
Q

Labetalol (Normodyne, Trandate):

A

hypertension, pheochromocytoma, and clonidine withdrawal

59
Q

Phentolamine (Regitine) Non-selective Alpha blocker

A
  • Diagnosis of pheochromocytoma-rare tumor of the adrenal gland that causes toomuch release of epinephrine and norepinephrine
  • Management of severe hypertension during pheochromocytoma surgery
  • Prevention of cell death with IV infiltration of norepinephrine or dopamine
60
Q

Phentolamine (Regitine) Non-selective Alpha blocker DRUG Interactions

A

Ephedrine, Epinephrine, Alcohol

61
Q

Doxazosin (Cardura):

A

used to treat hypertension; also effective in the treatment of benign prostatic hypertrophy
Drug Interactions with Vasodilators and antihypertensives.

62
Q

Prazosin (Minipress):

A

used to treat hypertension, alone or in combination with other drugs. Drug Interactions with Vasodilators and antihypertensives

63
Q

Terazosin (Hytrin):

A

used to treat hypertension as well as BPH. Drug Interactions with Vasodilators and antihypertensives

64
Q

Tamsulosin (Flomax) and alfuzosin (Uroxatral):

A

used in the treatment of BPH only Drug Interactions with Vasodilators and antihypertensives

65
Q

Propranolol (Inderal)-

A

HTN, angina, migraine. Essential tremor

66
Q

Sotalol (Betapace, Betapace AF)-

A

Betapace used in prevention of life-threatening ventricular arrhythmias, Betapace AF used in maintenance of NSR in afib/aflutter pts

67
Q

Timolol (Timoptic)-

A

HTN, prevention of reinfarction after MI, migraine prophylaxis, reduces IOP in open-angle glaucoma in the opthlamic form

68
Q

Nadolol (Corgard)-

A

HTN, chronic angina

69
Q

Nebivolol (Bystolic)-

A

HTN

70
Q

Beta1 selective beta blockers

A

***Preferred for patients who smoke or have asthma, obstructive pulmonary disease, or seasonal or allergic rhinitis
Because Do not usually block beta2-receptor sites, including the sympathetic bronchodilation

71
Q

Atenolol (Tenormin)-

A

MI, chronic angina, HTN

72
Q

Bisoprolol (Zebeta)-

A

HTN

73
Q

Metoprolol (Lopressor, Toprol XL)-

A

HTN, CHF, MI

74
Q

Esmolol (Brevibloc)-

A

Tx of supraventricular tachycardias (aflutter/afib)

75
Q

Beta1 Selective adrenergic blockers drug to drug interactions

A

NSAIDs

IV lidocaine

76
Q

Drug of choice for adult with HTN

A

Bisoprolol

77
Q

Drugs used to treat HTN in Children

A

prazosin is used to treat hypertension, and phentolamine, which is used during surgery for pheochromocytoma.

78
Q

Adrenergic blockers associated with more CNS adverse effects

A

pranolol and metoprolol

79
Q

Drug-food

A

VitK -Coumadin

Dairy/ca2+-tetracycline

80
Q

Drug-lab tests

A

Carbenicillin-=>serum na+

Fragmin= >increase AST liver fx.

nursing (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions