Pharmacology

Question 1

Cross link peptidoglycan in cell walls

Answer 1

Transpeptidases

Question 2

Type of hypersensitivity in penicillin-induced hemolytic anemia

Answer 2

Type II Hypersensitivity

Question 3

Penicillin that penetrate porin channel of gram-negative bacteria

Answer 3

Aminopenicillin

Question 4

Proximal tubule enzyme that degrades imipinem - rationale for giving cilastatin

Answer 4

dehydropeptidase I

Question 5

Binds penicillin binding protein 3 found in G- bacteria

Answer 5

Aztreonam

Question 6

Hypoprothrombinemia

N-methylthiotetrazole (NMTT) side chains

Answer 6

Cefotetan, cefazolin

Question 7

Cephs with Disulfiram reaction

Answer 7

Cefoperazone, cefamandole, and cefotetan

Question 8

Converted to THF
• Does not require dihydrofolate reductase
Rescue for methotrexate toxicity

Answer 8

Leucovorin/ Folinic acid

Question 9

Antibiotics that block initiation of protein synthesis

Answer 9

Aminoglycosides

Question 10

Lysozymes are enzymes that kill bacteria by cleaving what part of the cell wall?

Answer 10

Β1 –> 4 glycosidic bond between NAG and NAM

Question 11

What antibacterial is only effective against Gram- negative aerobic rods?

Answer 11

Aztreonam