Pharmacology Flashcards
What is the MOA of Donepezil, Galantamine and Rivastigmine?
Reversible ACh esterase inhibitor
What are the ADR’s of Donepezil?
Abnormal dreams, aggression, agitation, anorexia, diarrhoea, dizziness, fatigue, hallucinations, headache, insomnia
What are the CI’s of Donepezil?
Asthma, COPD, cardiac arrythmias
What are the ADR’s of Galantamine?
Abdominal pain, bradycardia, reduced appetite, depression, diarrhoea, dizziness
What are the CI’s of Galantamine?
GI pathology, cardiac arrhythmias, epileptic, COPD, asthma
What are the ADR’s of Rivastigmine?
Abdominal pain, agitation, anorexia, anxiety
What are the CI’s of Rivastigmine?
GI disease, COPD, asthma, epileptic
What is the MOA of Memantine?
NMDA receptor antagonist + nAChR antagonist
What are the ADR’s of Memantine?
Balance disorders, constipation, dizziness, drowsiness, dyspnoea, headache, hypertension
What are the CI’s of Memantine?
Epileptic