Pharmacology

Question 1

What is the MOA of Warfarin?

Answer 1

Competitive inhibitor of VKOR

Question 2

What are the ADR’s of Warfarin

Answer 2

Haemorrhage, hepatic dysfunction, jaundice, nausea, pancreatitis

Question 3

What are the CI’s of Warfarin?

Answer 3

Haemorrhagic CVA, excessive bleeding, NSAIDs, INR > 4.5

Question 4

What is the antidote of Warfarin?

Answer 4

Vit K

Question 5

What is the MOA of Clopidogrel?

Answer 5

Inhibitor of platelet P2Y12 ADP receptor = reduced response to collagen

Question 6

What are the ADR’s of Clopidogrel?

Answer 6

Abd. pain, bleeding disorders, diarrhoea, dyspepsia

Question 7

What are the CI’s of Clopidogrel?

Answer 7

Active bleeding, prior to surgery

Question 8

What is the MOA of Telenecteplase?

Answer 8

Form of tissue plasminogen activating factor (tPA)

tPA turns plasminogen > plasmin = rapidly dissolves clots so fibrinolysis

Question 9

What are the ADR’s of Telenecteplase?

Answer 9

Serious bleeds, re-perfusion pathologies

Question 10

What are the CI’s of Telenecteplase?

Answer 10

Recent haemorrhage, anti-coag/anti-plat drugs, aneurysm, aortic dissection

Question 11

What is the antidote of Telenecteplase?

Answer 11

Tranexamic acid