What cells are able to ingest lipid and turn into a foam cell?
Scavenger cell or macrophage (from monocytes)
What is the main difference in structure between a stable and unstable plaque?
Stable = fibrous cap intact Unstable = damaged fibrous cap
What does plaque rupture cause?
Trigger change from stable > unstable angina
What does the strength of fibrous cap depend on?
- How much collagen is in it
- How thick it is
- If theres any ongoing inflam
- What forces acting on it
What happens in eccentric atherosclerosis?
Leaves part of vessel capable of vasoconstriction so any physiological vasoconstriction will further decrease lumen = ischaemic without change in stability of plaque
What happens to areas of blood vessel subject to lower sheer stress?
More prone to atherogenesis = formation of fatty deposits in arteries
When is there an increased susceptibility to thrombus?
When there is…
- alteration in vasc wall - atheroslcerosis or endothelial
- alteration to flow - disrupted
- alteration in blood - increases viscosity or stagnation
What is the order of artery layers (out to in)?
Adventitia > external elastic lamina > muscularis media > internal elastic lamina > intima > endothelium
What is the difference between a thrombus and embolus?
Thrombus = blood clot in vein Embolus = anything that moves through BV until reaches vessel = too small
