Pharmacology Flashcards
Aa
Of each
Ac
Before meals
AD
Right ear
Ad lib
As desired
Amt
Amount
Aq
Water
AS
Left ear
AU
Both ears
Bid
Twice a day
BSA
Body surface area
C
With
Caps
Capsules
D/c, dc
Discontinue
Disp
Dispense
Dl
Deciliter
Elix
Elixir
Emul
Emulsion
Et
And
Fl
Fluid
Hr
Hour
Hs
Hour of sleep
K
Potassium
Mcg
Microgram
N
Normal
NaCl
Sodium chloride
NPO
Nothing by mouth
OD
Right eye
Ophth
Instill in eye
OS
Left eye
OTC
Over the counter
Otic
Instill in ear
OU
Both eyes
P
After
Pc
After meal
Per
By, with
PO
By mouth
Prn
As needed
Q
Each
Qh
Every hour
Q2h
Every 2 hours
Q6h
Every 6 hours
Qid
4 times a day
Qs
Quality sufficient
Rx
Prescription
S
Without
Sig
Label
Ss
1/2
STAT
Immediately
Tid
3 times a day
Pure food and drug act
1906
-first drug law passed in United States
-ensure consumer quality
-require label to include ingredients and warnings
-sets U.S. standards for making drugs
-united states pharmacopeia and national drug standards
—source approved medication and chemical formulas for approved drugs
Federal food, drug, and cosmetic act
1938
- law gives food and drug administration authority to oversee safety of drug
- FDA agency of Department of Health and Human service
- new products must be FDA approved
- prescription and non-prescription drugs must be shown effective and safe
- drug utilization review is required
- regulation to prevent tampering
- accurate labels with generic name included
- requires warning labels
Controlled substance act
1970
- enacted to help reduce abuse of legal and illegal drugs
- prescriber must register with Drug Enforcement Agency, obtain a DEA registration number, renew annually
- law is enforced by DEA through Department of Justice
Controlled drugs
- require an Rx due to potential for dependence, abuse, addiction
- medical facility on site responsibility: maintain 2 year inventory of controlled drug transaction
- securely store rx form at facility
- keep current drug reference book available at all times
- keep controlled substance locked securely
Physical dependence
Patient reliance on medication to relieve shaking, pain or other symptoms
Psychological dependance
Patient reliance on medication to relieve anxiety, stress, tension, other undesirable mental state
Drug schedule
Department of justice place drugs into specific categories (schedule) according to potential for abuse and dependance
Schedule I
Drugs with
- high abuse, addiction potential
- no medicinal use, no accepted safety for use
- heroin, mescaline, LSD
Schedule II
- high abuse, addiction potential
- medicinal use
- registered DEA license provider must sign Rx
- Rx must be furnished to pharmacy within 72 hours
- if stored at facility: must be locked, routinely counted, inventoried, dispensing record kept for 2 years
- cocaine, morphine, methadone, codeine, Nembutal, percodan, tylox
Schedule III
- lower physical dependance, high psychological dependance potential
- rx handwritten
- no DEA number required
- up to 5 refills in 6 months
- narcotics, amphetamine-like substance: barbiturates, amphetamine compounds, paregoric, fiorinal
Schedule IV
- lower abuse potential
- mild tranquilizer, hypnotic: diazepam, Librium, Valium, ambien
- rx may be written by MA, RN but signed by MD
- up to 5 refills in 6 months, may be refilled by phone
Schedule V
Drugs require written or oral Rx
- lomotil, robitussin, A-C
- may be written by MA, RN but signed by MD
- up to 5 refills in 6 months
United States Parmacopeia and national formulary (USP-NF)
- official source of information for drugs approved by FDA
- describe drug identification, strength, quality, purity
- updated every 5 years
United States pharmacopeia dispensing information (USP-DI)
-electronic version updated each quarter
-contains 2 volumes:
—volume 1: for prescribers, contains industry respected drug information
—volume 2: advice for patient, written in lay person language, explains proper use of medication, description, precautions, side effects
Physician Drug reference (PDR)
-most comprehensive, widely used reference
-organized into 5 categories
—section 1: white-manufacturers index
—section 2: pink-alphabetical arrangement of generic and brand name index
—section 3: blue-classification index
—section 4: gray-manufacturers photographic index displaying medication
—section 5: white-production information
—section 6: white-controlled substance categories, poison control center, drug information centers, sound-alike, look-alike drug names
PDR section 5
Provides detailed information for each drug
- Action: cellular change result from drug use, principal organ site of action
- cautions: particular risk of using drug, adversity reaction, other side effects, warnings when to discontinue use
- contraindication: condition which drug administer would be improper, undesirable
- indication: condition for drug is meant to be used
- interaction: other drug/food cause interaction alter drug effects, type of drug interaction
Antogonism
Type of drug interaction
-occur when presence of 1 drug decrease intensity or shortens duration of another drug effect
Potentiation
Type of drug interaction
-occur when 2 drugs taken together, 1 of them exaggerates action of another
Synergism
Type of drug interaction
-if 2 drugs taken together are similar in action, combined effect is greater than effect produced if each taken separately
Hypoglycemic
- use to lower blood glucose level of diabetic patient
- interacts: alcohol, sulfonamide antibacterial drug
- interaction results: further lowering blood sugar level, severe risk of hypoglycemia
Depressant of central nervous system
- sedatives, narcotic, analgesics, antihistamine, alcohol
- substance: any CNS depressant listed at left
- result: dangerous over sedation, respiratory failure
Anticoagulants
- substance: aspirin, non-steroidal, anti-inflammatory, drugs, alcohol, antibiotics
- result: increase anti-coagulant, effect and risk of abnormal bleeding
Certain type of tetracycline antibiotic
- substance: iron supplement, milk, antacids
- result: reduce effectiveness of antibiotic if taken within 1 hour before, 2 hours after antibiotic
Oral contraceptives
- substance: barbiturates, some types of antibiotic
- result: reduced effectiveness of contraceptive, increase risk of pregnancy
Monoamine, oxidase inhibitor, antidepressant
- substance: meperidine, decongestant, amphetamines, cheese, bananas, red wine, beer, yeast extract, chocolate
- result: dangerous rises in BP, risk of seizures, brain hemorrhage
Generic or official
- Common, general name given when drug is first produced
- usually based on chemical name
- name not protected by trademark
- drug less costly
Trade or brand name
- name, on FDA approval, manufacturer gives the drug
- name protected by trademark
Chemical
- scientific molecular structure of drug
- long and complicated
Local
Drug acts on limited area, which it is administered
Systemic
General effect
-drug is transported through bloodstream, carried to 1 or more tissues
Absorption
-drug moves into bloodstream from site of administered
-rate which drug passes from intestine into blood stream, amount of drug passing into bloodstream depends on
—drug form, pH of medication, drug concentration, amount of food in stomach, depth of breathing for inhalants
Distribution
- drug leaves bloodstream, pass into tissue space, cell bodies
- may pass across blood-brain barrier, placenta into fetus
Metabolism
- drug breakdown to another chemical within liver
- usually result inactivation of drug
- sometimes convert to active form after liver absorption
Elimination
- excrete in urine
- small amount via saliva, sweat, stool, breast milk, breathing, tears
Curative
Kill cause factor of condition or disease
Therapeutic
Relieve symptoms of disorder or disease
Destructive
Eliminate tumor or organism
Palliative
Provide patient comfort, no cure, relieve pain or other symptoms
Prophylactic
Lessen severity of disease or prevent condition or disease
Replacement
Replace missing substance normally found in body
Diagnostic
Test for allergies (antigen sera) Radiographic studies (dye injection)
Factor affecting drug action: age
—newborn: immature, geriatric: deteriorating-both sensitive to medication
—geriatric: metabolism gastrointestinal function, drug sensitivity, circulation are dosage consideration
—adult patient: dosage calculation based on age, weight
—child patient: dosage calculated basis of mg of drug/kg of body weight, body surface area considered in calculation
Factors affect drug action: body weight
Same dose of same drug will have lesser effect on patient weighing more, than weighing less
Cumulation
Accumulation of drug in body result in toxicity
- drug has greater effect and toxic side effects
- due to lack of elimination between administration
- other factors are weight, age, sex, environment, psychological, genetics, allergies
Factor affect drug action: Disease
Kidney, liver disease affect drug action
-drug action may begin the disease process affecting body organs
Factor affecting drug action: drug-drug interaction
One drug may potentially or lessen action of another drug
Factor affecting drug action: immune response
May cause body to develop antibodies, any future administration of same drug produce allergic reaction
Factor affect drug action: sex
Pregnant women, other women, men all affected differently by drugs
- IM medication are absorbed more quickly by men than women
- caution must be used with drug administration to pregnant women, so not to affect fetus
Factor affect drug action: tolerance
Reduce responsiveness to drug
-may be inherited or acquired by use of drug over length of time
Adverse reaction
Include ototoxicity, tinnitus, photosensitivity, nephrotoxicity
Toxic effects
Poisonous effect result of idiosyncrasies, single overdose, accumulation in blood level over time
Side effects
- predictable reaction to drug, can be expected to occur due to way drug work on different tissues
- are inevitable for most type of drugs
Angiotensin-converting enzyme inhibitors side effects
Dizziness, dry mouth, vomiting, cough, rash
Antibiotics side effects
Diarrhea , thrush, rash
Anticholinergic drugs side effects
Blurred vision, dry mouth, urine retention
Antidepressant side effect
Drowsiness, dry mouth, blur vision, constipation
Antihistamines side effects
Dizziness, drowsiness, clumsiness
Barbiturates side effects
Dizziness, drowsiness, clumsiness