Pharmacology

Question 1

are liquid preparations of drugs fast or slow absorbed?

Answer 1

fast

Question 2

in what form are drugs usually absorbed in?

What influences rate of absorption?

Answer 2

uncharged form

way in which the drug breaks down and dissolves

Question 3

what is tmax, Cmax, and F?

Answer 3

time to peak plasma level
peak plasma level
bioavailability

Question 4

why should you prescribe the same brand for some drugs?

Answer 4

pharmacokinetics can be altered

Question 5

what are enteric coat and sustained release drug preparations?
What are 2 reasons for using a SR prep?

Answer 5

formulated to resist dissolution

Reduce rate of absorption and prolong action
Deliver drug to specific region of GI-tract

Question 6

What’s the half-life of morphine?

Answer 6

2/3hrs short half life

Question 7

What is acid-labile and give a drug example

Answer 7

when contacts the stomach acid, does not work

omeprazole

Question 8

Other than tablets, what’s another SR prep?

Answer 8

applied as patches

Question 9

what’s the half-life of insulin?

Answer 9

10 mins

Question 10

What are depot injections?

Answer 10

Used to aid compliance with injections weekly/monthly
Absorption by use of thick oils that slow down rate of diffusion from injection site
Avoids first pass metabolism: careful of bioequivalence