Pharmacology Flashcards
At rest, a neutron is positively or negatively charged?
Negative
There are two types of receptors, what are they?
- Ion chanels
2. G-Protein coupled
Ion channel and G-Protein coupled things are both examples of
Neuroreceptors
Of the two types of receptors we learned about, which work through ‘second messengers’?
G-Protein receptors
Neurotransmitters can fall into two categories based on their impact on the post-synaptic neutron. What are those categories?
Excitatory or inhibitory
Are excitatory neurotransmitters are typically found in long or short neutrons?
LONG
Are inhibitory neurotransmitters are typically found in long or short neutrons?
SHORT
Based on the slides, where in the brain does it seem that Serotonin comes from?
Raphe Nuclei
What is the Raphe Nuclei associated with?
Production of Serotonin
Based on the slides, where in the brain does it seem that Norepinephrine comes from?
Locus Coeruleus
What is the Locus Coeruleus associated with?
Production of Norepinephrine
Based on the slides, where does it seem that Dopamine comes from?
Substantial Nigra (SN)
and
Ventral Tegmental Area (VTA)
The Substantial Nigra (SN) and Ventral Tegmental Area (VTA) are associated with what?
Production of Dopamine
What are the seven stages of the neurotransmitter cycle?
- Synthesis
- Release from synaptic vesicles
- Binds to receptors
- Influence post-synaptic neuron
- Broken down (by enzymes)
- Reuptake of transmitter
- Formation and storage in synaptic vesicles
When a drug acts as an agonist, what is it doing to the relevant receptors?
Binding and activating like a natural compound…
What were the four ‘non-traditional’ neurotransmitters discussed in the slides?
- Peptides
- Nucleosides
- Lipids
- Gases
What are the two most common neurotransmitters in the CNS?
Glutamate and GABA, baby
Who is the main excitatory neurotransmitter?
GLUTAMATE
What is Glutamate made of?
Glutamic Acid, of course
Is Glutamate an amino acid?
Yup
Can Glutamate be synthesised in your toe?
Nope, it must be synthesised in the brain
It can’t pass the blood-brain barrier
Of the four major types of Glutamate receptors, which is the one Olivia wants us to worry about?
NMDA receptor
How many binding sites has your NMDA receptor?
At least 6
Is the NMDA receptor a G-Protein or Ion Channel variety?
Ion Channel