Pharmacology Flashcards
1
Q
Unasyn:
- generic name
- category
- MOA
- indications
- coverage
A
- Ampicillin/Sulbactam
- Penicillin/beta-lactamase inhibitor
- Inhibits bacterial cell wall synthesis, leading to cell lysis.
- Osteomyelitis, Orbital cellulitis, Bite wounds, Pyelonephritis
- (+)gram+, (+)gram-, (+)anaerobe, (-)pseudomonas, (-)MRSA
2
Q
Clindamycin
- category
- MOA
- indications
- coverage
- cautions
A
- Lincosamide
- Prevent bacterial replication in a bacteriostatic mechanism by interfering with the synthesis of proteins.
- Skin infxn (MRSA suspicion), Strep throat (alt to PCN), Odontogenic infxn (alt to PCN)
- (+)gram+, (+)anaerobe, (+)MRSA, (-)gram-, (-)pseudomonas
- Can be RF for C. diff
3
Q
Zosyn:
- generic name
- category
- MOA
- indications
- coverage
A
- Piperacillin/tazobactam
- Penicillin/beta-lactamase inhibitor
- Inhibits material cell wall synthesis, leading to cell lysis. Beta-lactamase inhibitor.
- Intra-abdominal infxn (appendicitis, diverticulitis, intra-abdominal abscess), Skin infections (if concerned about pseudomonas [DM]), Pneumonia (if worried about pseudomonas)
- (+)gram+, (+) gram-, (+) anaerobe, (+) pseudomonas, (-) MRSA, (-) atypical bacteria
4
Q
Rocephin
- generic
- category
- MOA
- indications
- coverage
A
- Ceftriaxone
- 3rd gen cephalosporin
- Inhibits bacterial cell wall synthesis, leading to lysis
- Gonococcall infxn, Complicated UTI (pyelonephritis)
- (+)gram+, (+)gram-, (-)anaerobe, (-)pseudomonas, (-)MRSA
5
Q
Vancomycin
- category
- MOA
- indications
- coverage
A
- Glycopeptide
- Inhibits bacterial cell wall synthesis
- C. diff infxn (oral intact), Osteomyelitis, prosthetic joint infxn, Skin infxn (MRSA suspected), Surgical site infxn
- (+)gram+, (+)MRSA, (-)gram-, (-)anaerobe, (-)pseudomonas
6
Q
Azithromycin
- brand name
- category
- MOA
- indications
- coverage
A
- Zithromax, Z-pak
- Macrolide
- Inhibits RNA-dependent protein synthesis at the chain elongation step; binds to the 50S ribosomal subunit resulting in blockage of transpeptidation
- COPD exacerbations, infectious diarrhea, Pneumonia CAP, Chlamydia, Strep pharyngitis (alt for PCN)
- (+/-)gram+, (+)atypical bacteria, (-)gram-, (-)anaerobic, (-)pseudomonas, (-)MRSA
7
Q
Augmentin
- generic name
- category
- MOA
- indications
- coverage
A
- Amoxicillin/clavulanate
- Penicillin/beta-lactamase inhibitor
- Clavulanic acid binds and inhibits beta-lactamases that inactivate amoxicillin resulting in amoxicillin having an expanded spectrum of activity. Amoxicillin inhibits bacterial wall synthesis, leading to lysis.
- Bite wound, COPD exacerbations, Diabetic foot infxn, Odontogenic infxn, Peritonsillar infxn, Otitis media, Strep pharyngitis (chronic carriage)
- (+)gram+, (+)gram-, (+)anaerobe, (-)pseudomonas, (-)MRSA, (-)atypical bacteria
8
Q
Cephalosporins
A
*
9
Q
Keflex
A
*
10
Q
Macrobid
A
*
11
Q
Cipro
A
*
12
Q
Flagyl
A
*
