Pharmacology Flashcards
1
Q
List two 1st generation cephalosporins
A
- Cefazolin
- Cephalexin
2
Q
List the characteristics of cefazolin
A
- Very good for staph & Strep coverage, OK for community GNR
- Perfect agent for skin infections, also for community UTIs
- Only administered IV
3
Q
List the characteristics of cephalexin
A
- Very good for staph & Strep coverage, OK for community GNR
- Perfect agen for skin infections, also for community UTIs
- Only administered orally
4
Q
List 4 2nd generation cephalosporins
A
- Cefuroxime
- Cefamandole
- Cefotetan
- Cefoxitin
5
Q
List the characterisrics of Cefuroxime
A
6
Q
List the characteristics of Cefamandole
A
- 2nd generation cephalosporin
- Contains a methylthiotetrazole (MTT) side chain
- MTT interfers with vitamin K-dependent y-carboxylation →
7
Q
List the characteristics of cefotetan
A
8
Q
List the characteristics of cefoxitin
A
- 2nd generation cephalosporin
- Loses Staph coverage, good community GNR, but the key is outstanding anaerobic coverage
- Lacks MTT moiety
9
Q
List 5 3rd generation cephalosporins
A
- Ceftriaxone
- Cefotaxime
- Ceftizoxime
- Cefixime
- Cefepime
10
Q
List the characteristics of Ceftriaxone
A
11
Q
List the characteristics of Cefotaxime
A
- 3rd generation cephalosporin
- Best Strep coverage of all cephalosporins, loses most of Staph coverage, excellent community GNR but no nosocomial GNR coverage
- Doses 3X/day (8 hr effect)
12
Q
List the characteristics of Ceftizoxime
A
- 3rd generation cephalosporin
- Best Strep coverage of all cephalosporins, loses most of Staph coverage, excellent community GNR but no nosocomial GNR coverage
- Doses 3X/day (8 hr effect)
- Expanded anaerobic coverage
13
Q
List the characteristics of Ceftazidime
A
14
Q
List the characteristics of Cefixime
A
15
Q
Name an example of 4th generation cephalosporin
A
Cefepime