Pharmacology

Question 1

Mechanism of action of leuprolide

Answer 1

GnRH analog

Question 2

Coagulation factors that are increased in response to estrogens

Answer 2

2, 7, 9, and 10

Question 3

Mechanism of action of clomiphene

Answer 3

Antagonist of estrogen receptors in hypothalamus, increasing LH and FSH

Question 4

Mechanism of action of tamoxifen

Answer 4

Estrogen receptor antagonist at breast, and agonist at bone and uterus

Question 5

Mechanism of action of raloxifene

Answer 5

Estrogen receptor antagonist at breast, and agonist at bone

Question 6

Examples of aromatase inhibitors

Answer 6

Anastrozole, letrosole, exemestane

Question 7

Mechanism of action of mifepristone

Answer 7

Competitive inhibitor of progestins

Question 8

Contraindications of combined contraception

Answer 8

• Smokers older than 35
• Pts with increased risk of CV disease
• Migraine with aura
• Breast cancer

Question 9

Mechanism of action of terbutaline and ritodrine

Answer 9

Beta 2 agonists that relax the uterus

Question 10

Mechanism of action of danazol

Answer 10

Synthetic androgen that acts as partial agonist at androgen receptors

Question 11

Mechanism of action of finasteride

Answer 11

5alpha reductase inhibitor

Question 12

Mechanism of action of flutamide

Answer 12

Competitive inhibitor at androgen receptors

Question 13

Mechanism of action of tamsulosin

Answer 13

Alpha1 A/D receptors (Alpha1B found in vasculature)

Question 14

Ophthalmologic adverse effect of phosphodiesterase type 5 inhibitors

Answer 14

Cyanopia (blue-tinted vision)

Question 15

Adverse effect of sulfonamides (taken by the mother) on newborns

Answer 15

Kernicterus

Question 16

Mechanism of action of dinoprostone

Answer 16

Prostaglandin E2 analog

Question 17

Mechanism of action of podophyllum

Answer 17

Binds to microtubule and stops mktosis in metaphase