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Reproductive Kaplan > Pathology > Flashcards

Pathology Flashcards

1
Q

Vaginal squamous cell carcinoma is found in which part of the vagina

A

Upper 1/3 (paramesonephric duct origin)

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2
Q

Theca luteum cysts area associated with which pathologies

A
  • Complete mole

* Choriocarcinoma

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3
Q

Biopsy finding in a dysgerminoma/seminoma

A

Undifferentiated germ cells (“fried egg” appearance) with a lymphocytic infiltrate

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4
Q

Type of cells that can be found in a gonadoblastoma

A

Sertoli or granulosa cells

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5
Q

Characteristic biopsy finding in yolk sac tumors

A

Schiller-Duval bodies (papillary structure around central blood vessel - “glomerulus-like” structures)

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6
Q

Serologic marker of yolk sac tumors

A

Alpha-fetoprotein

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7
Q

Serologic marker of choriocarcinoma

A

Beta-hCG

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8
Q

Characteristic biopsy finding in granulosa cell tumors

A

Call-Exner bodies (coffee-bean shaped secretory globules)

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9
Q

Gene that increases breast cancer risk in both men and women

A

BRCA2

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10
Q

Gene that increases breast and ovarian cancer risk

A

BRCA1

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11
Q

Serologic marker for seminomas

A

Alkaline phosphatase

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12
Q

Characteristic biopsy finding in Leydig cell tumors

A

Reinke crystals (cylindrical crystalloid eosinophilic bodies in the cytoplasm)

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13
Q

Most common testicular cancer in elderly men

A

Lymphomas

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14
Q

Sacrococcygeal teratomas arise from which embryonic structure

A

Primitive streak

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15
Q

Fibrosis of which part of the male genitalia is seen in Klinefelter syndrome

A

Seminiferous tubules

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16
Q

Hormones that are decreased in Klinefelter syndrome

A
  • Testosterone

* Inhibin B

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17
Q

Hormones that are increased in Klinefelter syndrome

A
  • FSH
  • LH
  • Estrogen
18
Q

Renal anomaly associated with Turner syndrome

A

Horseshoe kidney

19
Q

Deletion of which gene results in short stature in patients with Turner syndrome

A

SHOX gene

20
Q

Mechanism of action of the E6 gene product

A

Inhibits p53

21
Q

Mechanism of action of E7 gene product

A

Inhibits RB

22
Q

Most common malignant stromal tumor

A

Granulosa cell tumor

23
Q

Biopsy finding in serous cystadenocarcinoma

A

Psamomma bodies and papillary structures

24
Q

Serologic markers for dysgerminomas

A

hCG and LH

25
Q

Most common cause of nipple discharge

A

Intraductal papilloma

26
Q

Most common testicular tumor in boys younger than 3 years

A

Yolk sac tumor

27
Q

Painful, hemorrhagic, testicular mass with necrosis and a glandular/papillary morphology

A

Embryonal carcinoma

28
Q

Failure of the testes to attach to the inner lining of the scrotum can lead to which pathology

A

Testicular torsion

29
Q

Testicular mass comprised of immature, primitive cells that may produce glands, and with hemorrhagic necrosis

A

Embryonal carcinoma

30
Q

Chemotherapy in this tumor can result in differentiation to another type of germ cell tumor

A

Embryonal carcinoma

31
Q

Serologic markers for embryonal carcinoma

A

AFP and beta-hCG

32
Q

Periareolar mass with green-brown nipple discharge

A

Mammary duct ectasia

33
Q

Subtype of invasive ductal carcinoma that is associated with BRCA1 mutations

A

Medullary carcinoma

34
Q

Characteristic biopsy finding of invasive lobular carcinoma

A

Grows in a single-file pattern, may exhibit signet cell morphology

35
Q

Mayer-Rokitansky-Küster-Hauser syndrome is associated with what renal abnormality

A

Absence of kidney

36
Q

Type of bone mets seen in breast cancer

A

Lytic and blastic

37
Q

Type of breast cancer associated with Paget’s disease

A

Invasive or in situ ductal cell carcinoma

38
Q

Fibrocystic change subtype that increases the risk for developing invasive carcinoma of the breast

A

Sclerosing adenosis and lobular hyperplasia with atypia

39
Q

Epidemiologic profile of patients with ductal ectasia

A

Elderly women with a smoking history

40
Q

Prenatal conditions that are associated with the development of congenital torticollis

A

Birth trauma and malposition of the head in utero

41
Q

Metabolic disturbance in a neonate born to a diabetic mother

A

Transient hypoglycemia

Reproductive Kaplan (3 decks)

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