Pharmacology Flashcards

1
Q

Drugs that decrease peripheral conversion of T4 to T3

A

PTU and beta blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sulfonylurea that produces a disulfiram-like effect

A

Chlorpropamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Mechanism of action of acarbose

A

Inhibits alpha glucosidase in small intestinal brush border

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Mechanism of action of thiazolidinediones

A

Bind to PPARs to increase the transcription of insulin-responsive genes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Mechanism of action of exenatide

A

GLP-1 receptor agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mechanism of action of sitagliptin

A

Inhibits DPP-4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

GH analog that is used to treat HIV-associated lipodystrophy

A

Tesamorelin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Duration of action of lispro insulin

A

3 to 4 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Duration of action of regular insulin

A

5 to 7 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Duration of action of NPH insulin

A

18 to 24 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Duration of action of glargine insulin

A

More than 24 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Rapid acting insulins

A

Lispro, aspart, and glulisine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Most important adverse effecf of first generation sulfonylureas

A

Disulfiram-like effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Examples of first generation sulfonylureas

A

Chlorpropamide and tolbutamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Drugs used in diabetes mellitus that can cause weight gain, edema, and heart failure

A

Thiazolidinediones (glitazones)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Mechanism of action of meglitinides (nateglinide, repaglinide)

A

Bind to K channels on beta cell membranes (different site from that of sulfonylureas)

17
Q

Most common adverse effects of DPP-4 inhibitors

A

Mild urinary or respiratory infections

18
Q

Mechanism of action of amylin analogs (pramlintide)

A
  • Decreases gastric emptying
  • Decreases glucagon secretion
  • Decreases appetite
19
Q

Contraindication of sulfonylureas

A

Liver failure

20
Q

Mechanism of action of finasteride

A

Inhibition of 5alpha-reductase

21
Q

Mechanism of action of leuprolide

A

GnRH agonist

22
Q

Mechanism of action of anastrozole

A

Aromatase inhibitor

23
Q

Mechanism of action of flutamide

A

Impairs androgen receptor stimulation

24
Q

Effects of adiponectin secretion

A

Enhances insulin sensitivity and fatty acid oxidation

25
Mechanism of action of bicalutamide
Testosterone receptor antagonist
26
Mechanism of action of danazol
Synthetic steroid with androgenic and antiestrogenic effects
27
Gonadotropin that is more elevated in puberty
LH
28
Diuretics that decrease plasma calcium levels
Loop diuretics