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Rheumatology > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Examples of NSAIDs

A

Ibuprofen
diclofenac
Naproxen

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2
Q

Mode of action of NSAIDs

A

Selective or non-selective COX inhibitors

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3
Q

Adverse effects of NSAIDs

A 
tarry black stools
dyspepsia
gastritis 
peptic ulcer 
renal impairment
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4
Q

Examples of DMARDs

A

Methotrexate
Sulphasalazine
Hydroxychloroquine
Leflunomide

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5
Q

adverse effects of Methotrexate

A 
interstitial pneumonitis 
leucopenia 
thrombocytopenia 
heptatitis/cirrhosis 
rash/mouth ulcers 
teratogenic
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6
Q

adverse effects of Sulphasalazine

A 
neutropenia 
orange body fluids 
rashes 
oligospermia
heinz body anaemia
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7
Q

adverse effects of hydroxychloroquine

A

retinopathy

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8
Q

Examples of Biologics

A 
Anti-TNF: infliximab, etanercept 
Rituximab 
Tocilizumab 
Abatacept 
Ustekinamab
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9
Q

adverse effects of biologics

A

Infection - especially TB

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10
Q

contraindications to biologics

A

pulmonary fibrosis

Heart failure

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11
Q

Examples of corticosteroids

A

prednisolone
hydrocortisone
methylprednisolone
dexamethasone

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12
Q

adverse effects of corticosteroids

A 
weight gain 
muscle wasting 
osteoporosis 
cataracts 
glaucoma
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13
Q

Nephrotoxic rheumatoid drugs

A

Gold

penicillamine

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14
Q

is methotrexate safe in pregnancy

A

No - should be stopped at least 3 months before conception

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15
Q

DMARDs not safe in pregnancy

A

Methotrexate

Leflunomide

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16
Q

DMARDs safe in pregnancy

A

Hydroxychloroquine

Sulfasalazine

17
Q

Are NSAIDs safe in pregnancy

A

Only until 32 weeks - then should stopped due to causing early closure of ductus arteriosus

18
Q

How often is methotrexate taken by a patient

A

Weekly, not daily!

19
Q

What blood tests need to be monitored when a patient is on Methotrexate, and how often should they be taken

A

FBC, U&Es, LFTs

take before starting Tx, and repeat weekly until levels stabilised.
2-3 weekly thereafter

20
Q

What medication should be co-prescribed to a patient on Methotrexate and when should it be taken

A

Folic acid 5mg once weekly, 24h after methotrexate dose

21
Q

What is the starting dose for Methotrexate

A

7.5mg weekly

22
Q

What is the usual strength of one Methotrexate tablet

23
Q

What medications should NOT be co-prescribed with Methotrexate, and why

A

Trimethoprim or Co-trimoxazole

- increased risk of marrow aplasia (both anti folate drugs)

24
Q

rheumatoid drug causing blacky tarry stools

25
Q

rheumatoid drug that is

nephrotoxic + causes proteinuria

A

Gold

penicillamine

26
Q

rheumatoid drug causing thrombocytopenia

Rheumatology (9 decks)

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